マクロファージにおいてアポトーシスを誘発する能力がある非病原性細菌および/または弱毒化細菌、その製造方法ならびに使用

Title:

マクロファージにおいてアポトーシスを誘発する能力がある非病原性細菌および/または弱毒化細菌、その製造方法ならびに使用

Document Type and Number:

Japanese Patent JP2011510646

Kind Code:

A

Abstract:

The invention relates to an non-pathogenic and/or attenuated bacterium which is capable of inducing apoptosis in macrophages. Also disclosed are a process of manufacturing thereof and uses of such bacterium as a medicament.

Inventors:

Joachim Fenstelle
Catalina Garmbacher
Wolf El. Wrap
Werner Goebel
Christian hotts

Application Number:

JP2010544696A

Publication Date:

April 07, 2011

Filing Date:

January 29, 2009

Export Citation:

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Assignee:

AEterna Zentaris GmbH

International Classes:

C12N1/21; A61K31/282; A61K31/52; A61K35/74; A61K38/00; A61K39/04; A61K39/104; A61K39/106; A61K39/108; A61K39/112; A61K39/395; A61K45/00; A61P3/10; A61P29/00; A61P31/04; A61P31/12; A61P31/16; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P43/00; C12N1/20; C12N15/09

Domestic Patent References:

JPH09506254A	1997-06-24
JP2001519162A	2001-10-23
JPH09506254A	1997-06-24
JP2001519162A	2001-10-23

Foreign References:

US5972899A	1999-10-26
US5972899A	1999-10-26

Other References:

JPN7013002419; Ｍｏｌ．　Ｍｉｃｒｏｂｉｏｌ．Ｖｏｌ．１１，　Ｎｏ．４, 1994, ｐｐ．６１９-６２７
JPN7013002417; Ｃａｎｃｅｒ　Ｉｍｍｕｎｏｌ．　Ｉｍｍｕｎｏｔｈｅｒ．Ｖｏｌ．５７，　Ｎｏ．４, 200804, ｐｐ．５０７-５１５
JPN7013002418; Ｃｌｉｎ．　Ｍｉｃｒｏｂｉｏｌ．　Ｒｅｖ．Ｖｏｌ．５，　Ｎｏ．３, 1992, ｐｐ．３２８-３４２
JPN6013031427; Ｍｏｌ．　Ｍｉｃｒｏｂｉｏｌ．Ｖｏｌ．２１，　Ｎｏ．５, 1996, ｐｐ．１１０１-１１１５
JPN7013002417; Ｃａｎｃｅｒ　Ｉｍｍｕｎｏｌ．　Ｉｍｍｕｎｏｔｈｅｒ．Ｖｏｌ．５７，　Ｎｏ．４, 200804, ｐｐ．５０７-５１５
JPN7013002418; Ｃｌｉｎ．　Ｍｉｃｒｏｂｉｏｌ．　Ｒｅｖ．Ｖｏｌ．５，　Ｎｏ．３, 1992, ｐｐ．３２８-３４２
JPN6013031427; Ｍｏｌ．　Ｍｉｃｒｏｂｉｏｌ．Ｖｏｌ．２１，　Ｎｏ．５, 1996, ｐｐ．１１０１-１１１５

Attorney, Agent or Firm:

Toshio Yano
Takuya Kuno
Takahashi
Kimihiro Hoshi
Hiroyasu Ninomiya
Einzel Felix-Reinhard

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