Title:
METHODS FOR REGULATING BUD-HYPHA TRANSITION AND cAMP LEVELS IN CANDIDA ALBICANS
Document Type and Number:
WIPO Patent Application WO2005032469
Kind Code:
A3
Abstract:
The infection of a mammalian host by a microorganism can be prevented or treated through the alteration of the C. albicans homologue of the high affinity phosphodiesterase, PDE2, gene and/or the adenylate cyclase-associated protein gene. These methods may be used in the identification, prevention or treatment of microbial infection of mammalian hosts such as immunocompromised or immunosuppressed humans, for example, those having AIDS or undergoing transplantation or anticancer therapy.
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Inventors:
SUNDSTROM PAULA (US)
Application Number:
PCT/US2004/031865
Publication Date:
July 28, 2005
Filing Date:
September 29, 2004
Export Citation:
Assignee:
DARTMOUTH COLLEGE (US)
SUNDSTROM PAULA (US)
SUNDSTROM PAULA (US)
International Classes:
A61K38/00; A61K38/37; C07K14/40; A61K; (IPC1-7): A61K38/00
Foreign References:
| US20030104994A1 | 2003-06-05 |
Other References:
JUNG W. ET AL: "The cAMP phosphodiesterase encoded by CaPDE2 is required for hyphal development in Candida albicans", MICROBIOLOGY, vol. 149, 2003, pages 2961 - 2976, XP002986593
VISCOLI C. ET AL: "Candidemia in cancer patients: a prospective, multicenter surveillance study by the Invasive Fungal Infection Group (IFIG) of the European Organization for Research and Treatment of Cancer (EORTC).", CLINICAL INFECTIOUS DISEASE, vol. 28, 1999, pages 1071 - 1079, XP008046998
GHANNOUM M. ET AL: "Reduced virulence of Candida albicans PHR1 mutants", INFECTION AND IMMUNITY, vol. 63, no. 11, 1995, pages 4528 - 4530, XP002986594
BAHN Y. ET AL: "CAP1, an Adenylate Cyclase-Associated Protein Gene, Regulates Bud-Hypha Transitions, Filamentous Growth, and Cyclic AMP Levels and Is Required for Virulence of Candida albicans", JOURNAL OF BACTERIOLOGY, vol. 183, no. 10, 2001, pages 3211 - 3223, XP002986595
VISCOLI C. ET AL: "Candidemia in cancer patients: a prospective, multicenter surveillance study by the Invasive Fungal Infection Group (IFIG) of the European Organization for Research and Treatment of Cancer (EORTC).", CLINICAL INFECTIOUS DISEASE, vol. 28, 1999, pages 1071 - 1079, XP008046998
GHANNOUM M. ET AL: "Reduced virulence of Candida albicans PHR1 mutants", INFECTION AND IMMUNITY, vol. 63, no. 11, 1995, pages 4528 - 4530, XP002986594
BAHN Y. ET AL: "CAP1, an Adenylate Cyclase-Associated Protein Gene, Regulates Bud-Hypha Transitions, Filamentous Growth, and Cyclic AMP Levels and Is Required for Virulence of Candida albicans", JOURNAL OF BACTERIOLOGY, vol. 183, no. 10, 2001, pages 3211 - 3223, XP002986595
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