Title:
MICROPARTICLE AND PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2006/095668
Kind Code:
A1
Abstract:
A microparticle containing an amphiphilic polymer, composed of an internal nucleus consisting of a hydrophilic segment of the amphiphilic polymer and a hydrophobic outer layer consisting of a hydrophobic segment of the amphiphilic polymer, wherein a surface modifier binds to the hydrophobic outer layer. This microparticle effectively encloses a hydrophilic large-molecular-weight-having protein/peptide pharmaceutical, nucleic acid pharmaceutical, etc. in the internal nucleus consisting of a hydrophilic segment of amphiphilic polymer, thus being suitable for in vivo stabilization and absorption promotion.
Inventors:
KAKIZAWA YOSHINORI (JP)
AOKI TAKAO (JP)
IDA NOBUO (JP)
NISHIO REIJI (JP)
AOKI TAKAO (JP)
IDA NOBUO (JP)
NISHIO REIJI (JP)
Application Number:
PCT/JP2006/304236
Publication Date:
September 14, 2006
Filing Date:
March 06, 2006
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
KAKIZAWA YOSHINORI (JP)
AOKI TAKAO (JP)
IDA NOBUO (JP)
NISHIO REIJI (JP)
KAKIZAWA YOSHINORI (JP)
AOKI TAKAO (JP)
IDA NOBUO (JP)
NISHIO REIJI (JP)
International Classes:
C08G81/00; A61K9/14; A61K9/50; A61K31/7105; A61K31/711; A61K38/00; A61K47/32; A61K47/34
Domestic Patent References:
| WO1996020698A2 | 1996-07-11 | |||
| WO1999062983A1 | 1999-12-09 | |||
| WO1997015287A1 | 1997-05-01 | |||
| WO1996033233A1 | 1996-10-24 | |||
| WO1999061512A1 | 1999-12-02 | |||
| WO2001032146A2 | 2001-05-10 | |||
| WO1996020698A2 | 1996-07-11 | |||
| WO1997015287A1 | 1997-05-01 |
Foreign References:
| JP2004175795A | 2004-06-24 | |||
| JPH11269097A | 1999-10-05 | |||
| JP2004018438A | 2004-01-22 | |||
| US20050003016A1 | 2005-01-06 |
Other References:
P.U. JANI: "Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 42, no. 12, 1990, pages 821 - 826
AHMED ET AL.: "Self-porating polymersome of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled relaes vesicles", JOURNAL OF CONTROLLED RELEASE, vol. 96, 2004, pages 37 - 53
LU ET AL.: "A method for the preparation of polymeric nanocapsules without stabilizer", JOURNAL OF CONTROLLED RELEASE, vol. 61, 1999, pages 107 - 112, XP004362968, DOI: doi:10.1016/S0168-3659(99)00112-1
SOPPIMATH ET AL.: "Biodegradable polymeric nanoparticles as drug delivery devices", JOURNAL OF CONTROLLED RELEASE, vol. 70, 2001, pages 1 - 20, XP002580484, DOI: doi:10.1016/S0168-3659(00)00339-4
AHMED ET AL.: "Self-porating polymersome of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled relaes vesicles", JOURNAL OF CONTROLLED RELEASE, vol. 96, 2004, pages 37 - 53
LU ET AL.: "A method for the preparation of polymeric nanocapsules without stabilizer", JOURNAL OF CONTROLLED RELEASE, vol. 61, 1999, pages 107 - 112, XP004362968, DOI: doi:10.1016/S0168-3659(99)00112-1
SOPPIMATH ET AL.: "Biodegradable polymeric nanoparticles as drug delivery devices", JOURNAL OF CONTROLLED RELEASE, vol. 70, 2001, pages 1 - 20, XP002580484, DOI: doi:10.1016/S0168-3659(00)00339-4
Attorney, Agent or Firm:
Iwami, Tomonori c/o Intellectual Property Department (TORAY INDUSTRIES INC., 1-1, Sonoyama 1-chom, Otsu-shi Shiga 58, JP)
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