NOVEL SALT OF QUINUCLIDINE DERIVATIVE

WIPO Patent Application WO/2006/095671

A1

An acid addition salt formed from (-)-(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline -2-carboxylic acid (3R)-quinuclidin-3-yl ester and an acid selected from the group consisting of (-)-(2S,3S)-tartaric acid, (+)-(2S,3S)-di-o-benzoyltartaric acid, (+)-(2S,3S)-di-o-(4-methylbenzoyl)tartaric acid, (-)-L-phenylalanine, benzenesulfonic acid, cyclohexanesulfamic acid, hydrobromic acid, naphthalene-2-sulfonic acid, sebacic acid, (+)-camphor-10-sulfonic acid, p-toluenesulfonic acid, ethanesulfonic acid, methanesulfonic acid and methyl phosphate. This salt does not show hygroscopicity in such a level that is not desirable for use as a pharmaceutical agent or an active ingredient of a pharmaceutical agent, and therefore is an extremely useful compound for use as a pharmaceutical agent or an active ingredient of a pharmaceutical agent.

HAYAKAWA MASAHIKO (JP)
SAMIZU KIYOHIRO (JP)
UEBAYASHI HIROSHI (JP)
IKEDA KEN (JP)
TAKEUCHI MAKOTO (JP)

PCT/JP2006/304241

September 14, 2006

March 06, 2006

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ASTELLAS PHARMA INC (JP)
HAYAKAWA MASAHIKO (JP)
SAMIZU KIYOHIRO (JP)
UEBAYASHI HIROSHI (JP)
IKEDA KEN (JP)
TAKEUCHI MAKOTO (JP)

C07D453/02; A61K31/435; A61K31/439; A61K31/4725; A61P1/00; A61P1/04; A61P1/06; A61P7/12; A61P11/00; A61P11/02; A61P11/06; A61P11/08; A61P13/00; A61P13/02; A61P13/10; A61P25/00; A61P27/16; A61P43/00

WO1996020194A1

1996-07-04

JP3701964B1	2005-10-05
JP2002104968A	2002-04-10
JPH107675A	1998-01-13

Morita, Hiroshi c/o Astellas Pharma Inc. (Intellectual Property 3-11, Nihonbashi-Honcho 2-chome, Chuo-k, Tokyo 11, JP)

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