Title:
MODIFICATION OF PLATELET ACTION BY FIBRINOGEN-COATED PARTICLES
Document Type and Number:
WIPO Patent Application WO1998055455
Kind Code:
A9
Abstract:
The invention relates to the interaction between protein or peptide-coated microspheres and the alpha IIb beta 3 receptor of activated platelets. Methods for identifying an antithrombocytopenic or putatively antithrombocytopenic composition by incubating a coated microsphere with activated human platelets and detecting phosphatidylinositol 4,5-biphosphate (PIP2) and phosphatidylinositol 4-phosphate (PIP) levels in the platelets are disclosed.
Inventors:
VICKERS JOHN D (CA)
YEN RICHARD C K (US)
YEN RICHARD C K (US)
Application Number:
PCT/US1998/011677
Publication Date:
May 06, 1999
Filing Date:
June 04, 1998
Export Citation:
Assignee:
HEMOSPHERE INC (US)
VICKERS JOHN D (CA)
YEN RICHARD C K (US)
VICKERS JOHN D (CA)
YEN RICHARD C K (US)
International Classes:
A61K9/16; A61K38/36; G01N33/86; (IPC1-7): A61K9/16; A01N37/18; A61K35/14
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