Title:
MODIFIED INTERLEUKIN 12 AND USE THEREOF IN PREPARING DRUGS FOR TREATING TUMOURS
Document Type and Number:
WIPO Patent Application WO/2017/041739
Kind Code:
A1
Abstract:
Provided are a modified interleukin 12 (nsIL-12) and a gene, a recombinant vector and a use thereof in preparing drugs for treating tumours.
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Inventors:
WANG YAOHE (CN)
WANG PENGJU (CN)
NICK LEMOINE (CN)
GAO DONGLING (CN)
WANG PENGJU (CN)
NICK LEMOINE (CN)
GAO DONGLING (CN)
Application Number:
PCT/CN2016/098527
Publication Date:
March 16, 2017
Filing Date:
September 09, 2016
Export Citation:
Assignee:
BEIJING BIO-TARGETING THERAPEUTICS TECH INC (CN)
UNIV ZHENGZHOU (CN)
UNIV ZHENGZHOU (CN)
International Classes:
C12N15/24; A61K38/20; A61K48/00; A61P35/00; C07K14/54; C12N15/861; C12N15/863; C12N15/869
Foreign References:
| CN101410529A | 2009-04-15 |
Other References:
DATABASE GENBANK DATABASE [O] 14 February 2002 (2002-02-14), XP 055378318, retrieved from NCBI Database accession no. AAL77817.1
DATABASE GENBANK DATABASE [O] 14 February 2002 (2002-02-14), XP 055378355, retrieved from NCBI Database accession no. AF401989
PAN, SUMIN ET AL.: "Enhancement of Canine Parvovirus VP2 DNA Vaccine Potency by Coadministration with Interleukin-12 Gene Expression Vector", CHINESE JOURNAL OF VETERINARY SCIENCE, vol. 32, no. 2, 29 February 2012 (2012-02-29), pages 196 - 201, XP009509901, ISSN: 1005-4545
XU, JINPING ET AL.: "Expression, Purification and Bioactivity Detection of Recombinant Human IL -12 in Argyogramma agnate", VIROLOGICA SINICA, vol. 17, no. 4, 30 November 2002 (2002-11-30), pages 340 - 343, XP 028493249, ISSN: 1003-5125
WANG, Z. ET AL.: "Combined IL-12 and GM-CSF gene therapy for murine hepatocellular carcinoma", CANCER GENE THERAPY, vol. 8, no. 10, 31 December 2001 (2001-12-31), pages 751 - 758, XP 055378359, ISSN: 0929-1903
See also references of EP 3348643A4
DATABASE GENBANK DATABASE [O] 14 February 2002 (2002-02-14), XP 055378355, retrieved from NCBI Database accession no. AF401989
PAN, SUMIN ET AL.: "Enhancement of Canine Parvovirus VP2 DNA Vaccine Potency by Coadministration with Interleukin-12 Gene Expression Vector", CHINESE JOURNAL OF VETERINARY SCIENCE, vol. 32, no. 2, 29 February 2012 (2012-02-29), pages 196 - 201, XP009509901, ISSN: 1005-4545
XU, JINPING ET AL.: "Expression, Purification and Bioactivity Detection of Recombinant Human IL -12 in Argyogramma agnate", VIROLOGICA SINICA, vol. 17, no. 4, 30 November 2002 (2002-11-30), pages 340 - 343, XP 028493249, ISSN: 1003-5125
WANG, Z. ET AL.: "Combined IL-12 and GM-CSF gene therapy for murine hepatocellular carcinoma", CANCER GENE THERAPY, vol. 8, no. 10, 31 December 2001 (2001-12-31), pages 751 - 758, XP 055378359, ISSN: 0929-1903
See also references of EP 3348643A4
Attorney, Agent or Firm:
BEIJING SAN GAO YONG XIN INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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