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Title:
MODULATORS OF FRAT-LRP INTERACTION IN THE TREATMENT OF BONE-RELATED DISEASES
Document Type and Number:
WIPO Patent Application WO2005105064
Kind Code:
A3
Abstract:
The present invention concerns the interaction between LRP5/6 and Frat 1 in the Wnt/ß-­catenin pathway and the implication of said interaction in the stabilisation of ß-catenin. The invention also relates to methods for selecting compounds acting as modulators of Frat-LRP interaction which are useful for treating bone-related diseases.

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Inventors:
FAUCHEU CHI (FR)
HAY ERIC (FR)
RAWADI GEORGES (FR)
ROMAN-ROMAN SERGIO (FR)
Application Number:
PCT/IB2005/001878
Publication Date:
February 16, 2006
Filing Date:
May 04, 2005
Export Citation:
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Assignee:
PROSKELIA PHARMACEUTICALS (FR)
FAUCHEU CHI (FR)
HAY ERIC (FR)
RAWADI GEORGES (FR)
ROMAN-ROMAN SERGIO (FR)
International Classes:
A61K31/00; A61K38/00; A61K45/00; G01N33/68; G01N33/92; (IPC1-7): A61K31/00; A61K38/00; A61K45/00; A61P19/00
Domestic Patent References:
WO2002081745A22002-10-17
Foreign References:
US20030009023A12003-01-09
US20030027151A12003-02-06
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