Title:
THIAZOLE-BASED NITRIC OXIDE DONORS FOR TREATING INFLAMMATORY BOWEL DISEASES
Document Type and Number:
WIPO Patent Application WO2005105065
Kind Code:
A3
Abstract:
Use of a novel class of NO-donating compounds, designed such that when NO is released from the compound a residue which is a naturally occurring metabolite is formed, in the treatment of inflammatory bowel diseases is disclosed. The compounds have the general formula.
Inventors:
ASSAF PETER (IL)
Application Number:
PCT/IL2005/000480
Publication Date:
December 15, 2005
Filing Date:
May 05, 2005
Export Citation:
Assignee:
RENOPHARM LTD (IL)
ASSAF PETER (IL)
ASSAF PETER (IL)
International Classes:
A61K31/427; C07D277/22; C07D277/24; C07D277/34; C07D277/36; C07D277/42; C07D417/04; C07D417/06; C07D417/10; C07D417/12; C07D495/04; (IPC1-7): A61K31/427; A61P1/00
Domestic Patent References:
| WO2001049275A2 | 2001-07-12 |
Foreign References:
| US6310052B1 | 2001-10-30 | |||
| US20050137191A1 | 2005-06-23 |
Other References:
CAVICCHI M ET AL: "Inhibition of inducible nitric oxide synthase in the human intestinal epithelial cell line, DLD-1, by the inducers of heme oxygenase 1, bismuth salts, heme, and nitric oxide donors", GUT, vol. 47, no. 6, December 2000 (2000-12-01), pages 771 - 778, XP009052245, ISSN: 0017-5749
SALAS AZUCENA ET AL: "Nitric oxide supplementation ameliorates dextran sulfate sodium-induced colitis in mice", LABORATORY INVESTIGATION, vol. 82, no. 5, May 2002 (2002-05-01), pages 597 - 607, XP001207172, ISSN: 0023-6837
UEDA SHIGEO ET AL: "Structure-activity relationships of 2-aminothiazole derivatives as inducible nitric oxide synthase inhibitor.", CHEMICAL & PHARMACEUTICAL BULLETIN. MAY 2004, vol. 52, no. 5, May 2004 (2004-05-01), pages 634 - 637, XP009052204, ISSN: 0009-2363
SALAS AZUCENA ET AL: "Nitric oxide supplementation ameliorates dextran sulfate sodium-induced colitis in mice", LABORATORY INVESTIGATION, vol. 82, no. 5, May 2002 (2002-05-01), pages 597 - 607, XP001207172, ISSN: 0023-6837
UEDA SHIGEO ET AL: "Structure-activity relationships of 2-aminothiazole derivatives as inducible nitric oxide synthase inhibitor.", CHEMICAL & PHARMACEUTICAL BULLETIN. MAY 2004, vol. 52, no. 5, May 2004 (2004-05-01), pages 634 - 637, XP009052204, ISSN: 0009-2363
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