Title:
MOLECULAR ANTIGEN ARRAY PRESENTING AMYLOID BETA
Document Type and Number:
WIPO Patent Application WO2002056907
Kind Code:
A3
Abstract:
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
Inventors:
RENNER WOLFGANG A (CH)
BACHMANN MARTIN (CH)
TISSOT ALAIN (CH)
MAURER PATRICK (CH)
LECHNER FRANZISKA (CH)
SEBBEL PETER (CH)
PIOSSEK CHRISTINE (CH)
ORTMANN RAINER (FR)
LUEOEND RAINER (CH)
STAUFENBIEL MATTHIAS (DE)
FREY PETER (CH)
BACHMANN MARTIN (CH)
TISSOT ALAIN (CH)
MAURER PATRICK (CH)
LECHNER FRANZISKA (CH)
SEBBEL PETER (CH)
PIOSSEK CHRISTINE (CH)
ORTMANN RAINER (FR)
LUEOEND RAINER (CH)
STAUFENBIEL MATTHIAS (DE)
FREY PETER (CH)
Application Number:
PCT/IB2002/000168
Publication Date:
December 27, 2002
Filing Date:
January 21, 2002
Export Citation:
Assignee:
CYTOS BIOTECHNOLOGY AG (CH)
NOVARTIS PHARMA AG (CH)
RENNER WOLFGANG A (CH)
BACHMANN MARTIN (CH)
TISSOT ALAIN (CH)
MAURER PATRICK (CH)
LECHNER FRANZISKA (CH)
SEBBEL PETER (CH)
PIOSSEK CHRISTINE (CH)
ORTMANN RAINER (FR)
LUEOEND RAINER (CH)
STAUFENBIEL MATTHIAS (DE)
FREY PETER (CH)
NOVARTIS PHARMA AG (CH)
RENNER WOLFGANG A (CH)
BACHMANN MARTIN (CH)
TISSOT ALAIN (CH)
MAURER PATRICK (CH)
LECHNER FRANZISKA (CH)
SEBBEL PETER (CH)
PIOSSEK CHRISTINE (CH)
ORTMANN RAINER (FR)
LUEOEND RAINER (CH)
STAUFENBIEL MATTHIAS (DE)
FREY PETER (CH)
International Classes:
A61K39/00; A61K35/76; A61K38/00; A61K39/02; A61K39/12; A61K39/29; A61K39/35; A61K39/385; A61K39/39; A61K47/48; A61P25/28; A61P29/00; A61P31/00; A61P35/00; A61P37/02; A61P37/08; A61P39/00; C07K14/005; C07K14/02; C07K14/08; C07K14/245; C07K14/52; C07K14/54; C07K16/00; C07K16/08; C07K16/22; C07K16/28; C07K16/40; C07K16/42; C12N15/40; A61K38/095; (IPC1-7): A61K39/385; A61P25/28
Domestic Patent References:
| WO2001062284A2 | 2001-08-30 | |||
| WO2000023955A1 | 2000-04-27 | |||
| WO2000032227A2 | 2000-06-08 | |||
| WO2001085208A2 | 2001-11-15 |
Other References:
SCHENK D ET AL: "Immunization with amyloid-beta attenuates Alzheimer -disease-like pathology in the PDAPP mouse [see comments]", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 400, no. 6740, 8 July 1999 (1999-07-08), pages 173 - 177, XP002154168, ISSN: 0028-0836
FRENKEL D ET AL: "Generation of auto-antibodies towards Alzheimer's disease vaccination.", VACCINE, vol. 19, no. 17-19, 2001, pages 2615 - 2619, XP002212470, ISSN: 0264-410X
FRENKEL D ET AL: "Generation of auto-antibodies towards Alzheimer's disease vaccination.", VACCINE, vol. 19, no. 17-19, 2001, pages 2615 - 2619, XP002212470, ISSN: 0264-410X
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