Title:
NANOEMULSION EYEDROP COMPOSITION CONTAINING CYCLOSPORINE AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2014/189251
Kind Code:
A1
Abstract:
The present invention relates to a nanoemulsion eyedrop composition and a method for preparing the same which increases the solubility of cyclosporine as an active ingredient and improves the stability of the eyedrop composition by mixing cyclosporine, a nonaqueous solvent, an emulsifier, and an aqueous solvent, and a method for preventing or treating dry eye syndrome using the same. The nanoemulsion eyedrop composition according to the present invention is characterized by having an average particle size of 200 nm or less, preferably 100 nm or less, and having a very narrow particle distribution. Therefore, the composition enables sterilizing filtration, improves stability, and has an excellent effect of clinically improving foreign body sensation and blurred vision, and thus can be effectively used for ophthalmic administration.
Inventors:
LEE JOON YOUB (KR)
SHIN YOUN JAE (KR)
RYU SANG-ROK (KR)
SHIN YOUN JAE (KR)
RYU SANG-ROK (KR)
Application Number:
PCT/KR2014/004489
Publication Date:
November 27, 2014
Filing Date:
May 20, 2014
Export Citation:
Assignee:
TAEJOON PHARM CO LTD (KR)
International Classes:
A61K38/13; A61K9/08; A61P27/02
Domestic Patent References:
| WO2012091278A2 | 2012-07-05 | |||
| WO1995031211A1 | 1995-11-23 |
Foreign References:
| CN101244256A | 2008-08-20 | |||
| US20120093894A1 | 2012-04-19 | |||
| US20060205639A1 | 2006-09-14 | |||
| US4839342A | 1989-06-13 | |||
| KR20080030828A | 2008-04-07 | |||
| US5660858A | 1997-08-26 | |||
| KR101008189B1 | 2011-01-17 |
Other References:
See also references of EP 3000474A4
Attorney, Agent or Firm:
AHN, So-Young (KR)
안소영 (KR)
안소영 (KR)
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