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Title:
NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/002577
Kind Code:
A1
Abstract:
Provided are compounds having excellent Syk-inhibitory activity and pharmaceutical compositions. Specifically provided are: nicotinamide derivatives represented by general formula (I) or salts thereof; and pharmaceutical compositions for the treatment of Syk-related diseases, which contain the nicotinamide derivatives or the salts thereof. In general formula (I), R1 is a halogen atom; R2 is C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl, C3-8 cycloalkyl, aryl, aralkyl (wherein the alkyl moiety has 1 to 6 carbon atoms), or a heterocyclic group, each being optionally substituted; R3 is aryl or a heterocyclic group, each being optionally substituted; R4 and R5 are each a hydrogen atom or the like; and R2 and R4 together with the nitrogen atom to which R2 and R4 are bonded may form an optionally substituted cyclic amino group.

Inventors:
FUJIWARA HIDEYASU (JP)
SATO KIMIHIKO (JP)
MIZUMOTO SHINSUKE (JP)
SATO YUICHIRO (JP)
KURIHARA HIDEKI (JP)
KUBO YOHEI (JP)
NAKATA HIYOKU (JP)
BABA YASUTAKA (JP)
TAMURA TAKASHI (JP)
KUNIYOSHI HIDENOBU (JP)
HAGIWARA SHINJI (JP)
YAMAMOTO MARI (JP)
Application Number:
PCT/JP2011/065530
Publication Date:
January 05, 2012
Filing Date:
June 30, 2011
Export Citation:
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Assignee:
FUJIFILM CORP (JP)
FUJIWARA HIDEYASU (JP)
SATO KIMIHIKO (JP)
MIZUMOTO SHINSUKE (JP)
SATO YUICHIRO (JP)
KURIHARA HIDEKI (JP)
KUBO YOHEI (JP)
NAKATA HIYOKU (JP)
BABA YASUTAKA (JP)
TAMURA TAKASHI (JP)
KUNIYOSHI HIDENOBU (JP)
HAGIWARA SHINJI (JP)
YAMAMOTO MARI (JP)
International Classes:
C07D213/82; A61K31/44; A61K31/443; A61K31/4439; A61K31/444; A61K31/4545; A61K31/4709; A61K31/496; A61K31/498; A61K31/4985; A61K31/506; A61K31/517; A61K31/5377; A61K31/5383; A61P7/00; A61P29/00; A61P37/00; A61P43/00; C07D215/40; C07D401/04; C07D401/12; C07D401/14; C07D405/14; C07D409/12; C07D409/14; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D471/04; C07D491/048; C07D491/056; C07D491/107; C07D498/04; C07D513/04
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WO2000075113A12000-12-14
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See also references of EP 2589592A4
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
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