Title:
NOVEL OPTICALLY ACTIVE ORGANOPHOSPHORUS COMPOUNDS, TRANSITION METAL COMPLEXES CONTAINING THE COMPOUNDS AS THE LIGAND, AND PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE COMPOUNDS WITH THE COMPLEXES
Document Type and Number:
WIPO Patent Application WO/2007/026441
Kind Code:
A1
Abstract:
Organophosphorus compounds represented by the general formula (1) (wherein R1 and R4 are each hydrogen, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, sulfonyloxy, halogeno, or the like; R2 and R3 are each an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, alkoxy, substituted or unsubstituted amino, or the like, or R2 and R3 together with the adjacent phosphorus atom may form a ring; n is 0 or 1; the norbornene ring may have another substituent in addition to those given in the formula or may be fused with another ring; and the phosphorus atom may take any of anti- and syn-configurations). The compounds are useful as the ligand for transition metal complex catalysts which make it possible to produce optically active compounds in high yields and asymmetric yields and which are excellent in general-purpose properties.
Inventors:
HAYASHI TAMIO (JP)
KITAYAMA KENJI (JP)
KITAYAMA KENJI (JP)
Application Number:
PCT/JP2006/304689
Publication Date:
March 08, 2007
Filing Date:
March 10, 2006
Export Citation:
Assignee:
UNIV KYOTO (JP)
DAICEL CHEM (JP)
HAYASHI TAMIO (JP)
KITAYAMA KENJI (JP)
DAICEL CHEM (JP)
HAYASHI TAMIO (JP)
KITAYAMA KENJI (JP)
International Classes:
C07F9/53; B01J31/24; C07B53/00; C07F9/50; C07F15/00
Foreign References:
| US3906061A | 1975-09-16 |
Other References:
SHINTANI R. ET AL.: "Chiral phosphine-olefin bidentate ligands in asymmetric catalysis: Rhodium-catalyzed asymmetric 1,4-addition of aryl boronic acids to maleimides", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 44, no. 29, 18 July 2005 (2005-07-18), pages 4611 - 4614, XP003001310
QUIN L.D. ET AL.: "Importance of the structure of the phosphorus functionality in allowing dihedral angle control of vicinal carbon-13-phosphorus-31 coupling. Carbon-13 NMR spectra of 7-substituted bicyclo[2.2.1]heptane derivatives", JOURNAL OF ORGANIC CHEMISTRY, vol. 43, no. 18, 1978, pages 3508 - 3512, XP003001311
QUIN L.D. ET AL.: "Importance of the structure of the phosphorus functionality in allowing dihedral angle control of vicinal carbon-13-phosphorus-31 coupling. Carbon-13 NMR spectra of 7-substituted bicyclo[2.2.1]heptane derivatives", JOURNAL OF ORGANIC CHEMISTRY, vol. 43, no. 18, 1978, pages 3508 - 3512, XP003001311
Attorney, Agent or Firm:
GOTO, Yukihisa et al. (Higashitenma 2-chome Kita-ku, Osaka-sh, Osaka 44, JP)
Download PDF: