Title:
NOVEL TRIHALOMETHIONINE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2007/077876
Kind Code:
A1
Abstract:
A compound represented by the formula (I) below is used as an active ingredient in a pharmaceutical product for treatment or prevention of infectious diseases caused by protozoa or bacterium. [Chemical formula 1] (I) In the general formula (I), X represents a halogen, Z represents -(CH2)m- wherein m is an integer of 1-5, and R represents one of the following (i)-(v). (i) hydrogen (ii) [Chemical formula 2] In this formula, n represents an integer of 0-5, R1's independently represent a hydrogen, a halogen, an alkoxy having 1-5 carbon atoms or an alkyl having 1-5 carbon atoms. (iii) [Chemical formula 3] In this formula, R2's independently represent a hydrogen, a halogen, an alkoxy having 1-5 carbon atoms or an alkyl having 1-5 carbon atoms. (iv) an alkyl having 1-5 carbon atoms (v) a hydroxyalkyl having 1-5 carbon atoms
Inventors:
NOZAKI TOMOYOSHI (JP)
TORU TAKESHI (JP)
SHIBATA NORIO (JP)
YAMAMOTO MASAICHI (JP)
TORU TAKESHI (JP)
SHIBATA NORIO (JP)
YAMAMOTO MASAICHI (JP)
Application Number:
PCT/JP2006/326067
Publication Date:
July 12, 2007
Filing Date:
December 27, 2006
Export Citation:
Assignee:
UNIV GUNMA NAT UNIV CORP (JP)
NAT UNIV CORP NAGOYA INST TECH (JP)
ARIGEN INC (JP)
NOZAKI TOMOYOSHI (JP)
TORU TAKESHI (JP)
SHIBATA NORIO (JP)
YAMAMOTO MASAICHI (JP)
NAT UNIV CORP NAGOYA INST TECH (JP)
ARIGEN INC (JP)
NOZAKI TOMOYOSHI (JP)
TORU TAKESHI (JP)
SHIBATA NORIO (JP)
YAMAMOTO MASAICHI (JP)
International Classes:
C07C323/59; A61K31/16; A61K31/165; A61K31/167; A61P33/02
Domestic Patent References:
| WO2004078349A1 | 2004-09-16 |
Foreign References:
| JPH07503705A | 1995-04-20 | |||
| JPH10504522A | 1998-05-06 | |||
| JP2003522815A | 2003-07-29 |
Other References:
HOUSTON M.E. ET AL.: "SYNTHESIS OF AND CHEMOTACTIC RESPONSES ELICITED BY fMET-LEU-PHE ANALOGS CONTAINING DIFLUORO- AND TRIFLUOROMETHIONINE", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 7, no. 23, 1997, pages 3007 - 3012, XP004136574
SEKO T. ET AL.: "Structure-Activity Study of L-Amino Acid-Based N-Type Calcium Channel Blockers", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, 2003, pages 1901 - 1913, XP003015096
SEKO T. ET AL.: "Structure-Activity Study of L-Amino Acid-Based N-Type Calcium Channel Blockers", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, 2003, pages 1901 - 1913, XP003015096
Attorney, Agent or Firm:
KAWAGUCHI, Yoshiyuki et al. (4-10 Higashi Nihonbashi 3-chom, Chuo-ku Tokyo, JP)
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