Title:
OPHTHALMIC COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2014/163142
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing an ophthalmic composition that holds promise for having a long-lasting effect and therapeutic effect on serious cases and is efficacious in treating dry eye. The ophthalmic composition comprises as an active ingredient a compound having a moisture adjusting effect in a digestive tract. A preferable example of the compound having a moisture adjusting effect in a digestive tract is a member selected from among bisacodyl, picosulfate and pharmaceutically acceptable salts thereof. The active ingredient of the ophthalmic composition according to the present invention can increase tear volume in an eye to be treated. When bisacodyl or picosulfate is used as the active ingredient of the ophthalmic composition according to the present invention, an increase in tear volume can be observed several minutes to several hours, for example 3 hours, after instillation.
Inventors:
OHASHI YUICHI (JP)
SHIRAISHI ATSUSHI (JP)
KOBAYASHI TAKESHI (JP)
SHIRAISHI ATSUSHI (JP)
KOBAYASHI TAKESHI (JP)
Application Number:
PCT/JP2014/059838
Publication Date:
October 09, 2014
Filing Date:
April 03, 2014
Export Citation:
Assignee:
NAT UNIV CORP EHIME UNIV (JP)
International Classes:
A61K45/00; A61K9/08; A61K31/4402; A61P27/04
Foreign References:
| JP2012224619A | 2012-11-15 | |||
| JP2002003377A | 2002-01-09 | |||
| JP2005538110A | 2005-12-15 |
Other References:
N.IKARASHI ET AL.: "The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE2 secretion from macrophages.", AMERICAN JOURNAL OF PHYSIOLOGY - GASTROINTESTINAL AND LIVER PHYSIOLOGY, vol. 301, 2011, pages G887 - G895
TAKESHI KOBAYASHI ET AL.: "Dry Eye Model Mouse no Ketsumakunonai Ruieki Choryuryo ni Oyobosu Bisacodyl Tengan no Eikyo", JAPAN CORNEA SOCIETY SOKAI .KERATOPLASTY SOCIETY OF JAPAN PROGRAM .SHOROKUSHU, 31 January 2014 (2014-01-31), pages 79, 027
TAKESHI KOBAYASHI ET AL.: "Dry Eye Model Mouse no Ketsumakunonai Ruieki Choryuryo ni Oyobosu Bisacodyl Tengan no Eikyo", JAPAN CORNEA SOCIETY SOKAI .KERATOPLASTY SOCIETY OF JAPAN PROGRAM .SHOROKUSHU, 31 January 2014 (2014-01-31), pages 79, 027
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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