Title:
PEPTIDE INHIBITORS OF HIV ENTRY
Document Type and Number:
WIPO Patent Application WO2002024735
Kind Code:
A3
Abstract:
Described herein are chimeric peptides comprising a soluble trimeric coiled-coil and all or a portion of the N-peptide region of HIV gp41. These molecules are stable, trimeric coiled-coils that inhibit HIV entry into cells, such as human cells. Such peptides can be further assessed to demonstrate their ability to serve as potent anti-HIV therapeutic molecules and thus, as therapeutic molecules or drugs.
Inventors:
ECKERT DEBRA M (US)
SUNTOKE TARA R (US)
KIM PETER S (US)
SUNTOKE TARA R (US)
KIM PETER S (US)
Application Number:
PCT/US2001/029637
Publication Date:
August 14, 2003
Filing Date:
September 21, 2001
Export Citation:
Assignee:
WHITEHEAD BIOMEDICAL INST (US)
ECKERT DEBRA M (US)
SUNTOKE TARA R (US)
KIM PETER S (US)
ECKERT DEBRA M (US)
SUNTOKE TARA R (US)
KIM PETER S (US)
International Classes:
A61K38/00; A61P31/18; C07K14/16; A61K48/00; C07K19/00; (IPC1-7): C07K14/16; A61K38/16; A61P31/18
Domestic Patent References:
| WO2000040616A1 | 2000-07-13 | |||
| WO2000006599A1 | 2000-02-10 |
Other References:
CHAN D C ET AL: "Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, December 1998 (1998-12-01), pages 15613 - 15617, XP002126805, ISSN: 0027-8424
ECKERT D M ET AL: "INHIBITING HIV-1 ENTRY: DISCOVERY OF D-PEPTIDE INHIBITORS THAT TARGET THE GP41 COILED-COIL POCKET", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 99, no. 1, 1 November 1999 (1999-11-01), pages 103 - 115, XP000982264, ISSN: 0092-8674
YANG XINZHEN ET AL: "Characterization of stable, soluble trimers containing complete ectodomains of human immunodeficiency virus type 1 envelope glycoproteins.", JOURNAL OF VIROLOGY, vol. 74, no. 12, June 2000 (2000-06-01), pages 5716 - 5725, XP002222730, ISSN: 0022-538X
JIANG SHIBO ET AL: "Development of HIV entry inhibitors targeted to the coiled-coil regions of gp41.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 269, no. 3, 24 March 2000 (2000-03-24), pages 641 - 646, XP002222731, ISSN: 0006-291X
ECKERT DEBRA M ET AL: "Crystal structure of GCN4-pIQI, a trimeric coiled coil with buried polar residues.", JOURNAL OF MOLECULAR BIOLOGY, vol. 284, no. 4, 11 December 1998 (1998-12-11), pages 859 - 865, XP002222732, ISSN: 0022-2836
SINGH MONA ET AL: "LearnCoil-VMF: Computational evidence for coiled-coil-like motifs in many viral membrane-fusion proteins.", JOURNAL OF MOLECULAR BIOLOGY, vol. 290, no. 5, 30 July 1999 (1999-07-30), pages 1031 - 1041, XP002222733, ISSN: 0022-2836
ECKERT D M ET AL: "INHIBITING HIV-1 ENTRY: DISCOVERY OF D-PEPTIDE INHIBITORS THAT TARGET THE GP41 COILED-COIL POCKET", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 99, no. 1, 1 November 1999 (1999-11-01), pages 103 - 115, XP000982264, ISSN: 0092-8674
YANG XINZHEN ET AL: "Characterization of stable, soluble trimers containing complete ectodomains of human immunodeficiency virus type 1 envelope glycoproteins.", JOURNAL OF VIROLOGY, vol. 74, no. 12, June 2000 (2000-06-01), pages 5716 - 5725, XP002222730, ISSN: 0022-538X
JIANG SHIBO ET AL: "Development of HIV entry inhibitors targeted to the coiled-coil regions of gp41.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 269, no. 3, 24 March 2000 (2000-03-24), pages 641 - 646, XP002222731, ISSN: 0006-291X
ECKERT DEBRA M ET AL: "Crystal structure of GCN4-pIQI, a trimeric coiled coil with buried polar residues.", JOURNAL OF MOLECULAR BIOLOGY, vol. 284, no. 4, 11 December 1998 (1998-12-11), pages 859 - 865, XP002222732, ISSN: 0022-2836
SINGH MONA ET AL: "LearnCoil-VMF: Computational evidence for coiled-coil-like motifs in many viral membrane-fusion proteins.", JOURNAL OF MOLECULAR BIOLOGY, vol. 290, no. 5, 30 July 1999 (1999-07-30), pages 1031 - 1041, XP002222733, ISSN: 0022-2836
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