Title:
PEPTIDE TAGS, COMPOSITIONS AND METHODS FOR SITE-SPECIFIC PROTEIN CONJUGATION
Document Type and Number:
WIPO Patent Application WO/2024/099368
Kind Code:
A1
Abstract:
It provides peptide tags and tag-modified protein that can be reacted with a chemical to specifically conjugating the chemical to the tag, to generate a protein-chemical conjugate, including antibody-drug conjugate. It also provides methods for preparing the tags, tag-modified proteins or protein-chemical conjugates. Further, it provides compositions and methods for treating diseases and cancers. It achieves significantly advantageous effect in conjugating a chemical to a desired position within a protein with high specificity and efficacy. The antibody-drug conjugates of it specifically target the target cells with significantly higher efficacy compared to antibody alone or drug alone.
Inventors:
DANG BOBO (CN)
GUO MENGZHUN (CN)
GUO MENGZHUN (CN)
Application Number:
PCT/CN2023/130506
Publication Date:
May 16, 2024
Filing Date:
November 08, 2023
Export Citation:
Assignee:
UNIV WESTLAKE (CN)
International Classes:
C07K7/06
Domestic Patent References:
| WO2013184514A1 | 2013-12-12 |
Foreign References:
| CN105143271A | 2015-12-09 | |||
| CN106659800A | 2017-05-10 | |||
| CN110177811A | 2019-08-27 | |||
| CN110709412A | 2020-01-17 |
Other References:
TINA GAUGER, FELIX WEIHS, SONJA MAYER, BERNHARD KRISMER, JAN LIESE, MELANIE KULL, RALPH BERTRAM: "Intracellular monitoring of target protein production in Staphylococcus aureus by peptide tag-induced reporter fluorescence : Tip-dependent reporter gene induction in S. aureus", MICROBIAL BIOTECHNOLOGY, vol. 5, no. 1, 1 January 2012 (2012-01-01), GB , pages 129 - 134, XP055449033, ISSN: 1751-7915, DOI: 10.1111/j.1751-7915.2011.00304.x
Attorney, Agent or Firm:
CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE (CN)
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