Title:
PEPTIDES OF CENP-A AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/023816
Kind Code:
A3
Abstract:
The invention relates to peptides of the CENP-A (CENtromer Protein A) and the use thereof for the diagnosis of systemic scleroses (SSc) and associated autoimmune diseases and for the differential and exclusion diagnosis. The invention further relates to the use of these peptides for immunoabsorption, as vaccines for producing tolerance and as immunogenic and antigenic composition for the production of antibodies in vivo and in vitro. Furthermore, it is possible to more distinctly differentiate patients suffering from SSc and related collagenoses.
Inventors:
MAHLER MICHAEL (DE)
Application Number:
PCT/EP2010/062623
Publication Date:
October 13, 2011
Filing Date:
August 30, 2010
Export Citation:
Assignee:
FOOKE LAB GMBH DR (DE)
MAHLER MICHAEL (DE)
MAHLER MICHAEL (DE)
International Classes:
C07K14/47
Foreign References:
| EP1489098A1 | 2004-12-22 |
Other References:
AKBARALI Y ET AL: "Fine specificity mapping of autoantigens targeted by anti-centromere autoantibodies", JOURNAL OF AUTOIMMUNITY, LONDON, GB, vol. 27, no. 4, 1 December 2006 (2006-12-01), pages 272 - 280, XP024910122, ISSN: 0896-8411, [retrieved on 20061201], DOI: DOI:10.1016/J.JAUT.2006.10.001
MAHLER MICHAEL ET AL: "Clinical and serological evaluation of a novel CENP-A peptide based ELISA.", ARTHRITIS RESEARCH & THERAPY 2010 LNKD- PUBMED:20487535, vol. 12, no. 3, 2010, pages R99, XP002655049, ISSN: 1478-6362
KESSENBROCK KAI ET AL: "Synthetic peptides: The future of patient management in systemic rheumatic diseases?", CURRENT MEDICINAL CHEMISTRY, vol. 14, no. 26, 2007, pages 2831 - 2838, XP002655050, ISSN: 0929-8673
MAHLER MICHAEL ET AL: "Clinical and serological evaluation of a novel CENP-A peptide based ELISA.", ARTHRITIS RESEARCH & THERAPY 2010 LNKD- PUBMED:20487535, vol. 12, no. 3, 2010, pages R99, XP002655049, ISSN: 1478-6362
KESSENBROCK KAI ET AL: "Synthetic peptides: The future of patient management in systemic rheumatic diseases?", CURRENT MEDICINAL CHEMISTRY, vol. 14, no. 26, 2007, pages 2831 - 2838, XP002655050, ISSN: 0929-8673
Attorney, Agent or Firm:
WEHLAN, Helmut et al. (Möllendorffstr. 49, Berlin, DE)
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