Title:
PHARMACEUTICAL PRODUCT WITH RETICULATED CRYSTALLINE MICROSTRUCTURE
Document Type and Number:
WIPO Patent Application WO2002083103
Kind Code:
A3
Abstract:
A pharmaceutical product comprising at least one therapeutic agent in crystalline form, said pharmaceutical product comprising at least one reticulated three-dimensional microstructure comprising: a network of substantially interconnecting walls, said walls being provided by a multiplicity of crystals arranged to at least partially abut each other; and a multiplicity of pores defined by said substantially interconnecting walls; wherein said therapeutic agent is characterised as having an aqueous solubility of not greater than about 1 in 30 to 1 in 100, weight/volume, when measured at a temperature in the range of 15 to 25 DEG C.
Inventors:
TOBYN MICHAEL JOHN (GB)
STANIFORTH JOHN NICHOLAS (GB)
CLINCH CHERYL (GB)
HEARN MATTHEW PAUL (GB)
STANIFORTH JOHN NICHOLAS (GB)
CLINCH CHERYL (GB)
HEARN MATTHEW PAUL (GB)
Application Number:
PCT/GB2002/001663
Publication Date:
April 10, 2003
Filing Date:
April 09, 2002
Export Citation:
Assignee:
VECTURA LTD (GB)
TOBYN MICHAEL JOHN (GB)
STANIFORTH JOHN NICHOLAS (GB)
CLINCH CHERYL (GB)
HEARN MATTHEW PAUL (GB)
TOBYN MICHAEL JOHN (GB)
STANIFORTH JOHN NICHOLAS (GB)
CLINCH CHERYL (GB)
HEARN MATTHEW PAUL (GB)
International Classes:
A61K9/16; A61K31/167; A61K31/192; A61K31/196; A61K31/343; A61K31/405; A61K31/4166; A61K31/4422; A61K31/519; A61K31/522; A61K31/616; A61K38/00; A61K47/02; A61K47/04; A61K47/26; A61P7/12; A61P9/12; A61P11/08; A61P25/08; A61P29/00; A61P31/10; A61P37/06; (IPC1-7): A61K9/16; C07C233/16; B01D9/00
Other References:
PARFITT K (ED.): "Martindale, 32nd ed.", 1999, PHARMACEUTICAL PRESS, LONDON, ISBN: 0 85369 429 X, XP002225504
WALSH D ET AL: "Crystal tectonics: Construction of reticulated calcium phosphate frameworks in bicontinuous reverse microemulsions.", SCIENCE, vol. 264, no. 5165, 1994, pages 1576 - 1578, XP002225503, ISSN: 0036-8075
WALSH D ET AL: "Morphosynthesis of calcium carbonate (vaterite) microsponges", ADVANCED MATERIALS, vol. 11, no. 4, 4 March 1999 (1999-03-04), pages 324 - 328, XP000802723, ISSN: 0935-9648
WALSH D ET AL: "Crystal tectonics: Construction of reticulated calcium phosphate frameworks in bicontinuous reverse microemulsions.", SCIENCE, vol. 264, no. 5165, 1994, pages 1576 - 1578, XP002225503, ISSN: 0036-8075
WALSH D ET AL: "Morphosynthesis of calcium carbonate (vaterite) microsponges", ADVANCED MATERIALS, vol. 11, no. 4, 4 March 1999 (1999-03-04), pages 324 - 328, XP000802723, ISSN: 0935-9648
Download PDF:
Previous Patent: CONTROLLED-RELEASE NIMODIPINE TABLET AND METHOD FOR PRODUCING THE SAME
Next Patent: COMPOSITION FOR ENHANCED ABSORPTION OF NSAIDS
Next Patent: COMPOSITION FOR ENHANCED ABSORPTION OF NSAIDS