Title:
PHARMACOLOGICAL AND/OR GENETIC ACTIVATOR FOR USE IN PRESERVING AND REGENERATING MUSCLE STRUCTURE AND FUNCTION BY BLOCKING SENESCENCE
Document Type and Number:
WIPO Patent Application WO/2023/012264
Kind Code:
A3
Abstract:
The invention relates to an activator for use in preserving and regenerating muscle structure and function. The invention is characterized in that said activator is an activator of the thyroid-stimulating hormone receptor (TSHR) signalling pathway in muscle stem cells (satellite cells) in order to preserve and regenerate muscle structure and function by blocking senescence. The invention also relates to a combination of a pharmacological activator for use according to the invention and of a genetic activator for use according to the invention, and also to an adenoviral vector comprising a thyroid-stimulating hormone receptor (TSHR) protein sequence of SEQ ID NO: 1, or a TSHR nucleotide sequence of SEQ ID NO: 2 for use as a medicament.
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Inventors:
TAGLIETTI VALENTINA (FR)
RELAIX FRÉDÉRIC (FR)
RELAIX FRÉDÉRIC (FR)
Application Number:
PCT/EP2022/071914
Publication Date:
March 30, 2023
Filing Date:
August 04, 2022
Export Citation:
Assignee:
ASS FRANCAISE CONTRE LES MYOPATHIES (FR)
UNIV PARIS EST CRETEIL UPEC (FR)
INST NAT SANTE RECH MED (FR)
UNIV PARIS EST CRETEIL UPEC (FR)
INST NAT SANTE RECH MED (FR)
International Classes:
C07K14/72; A61P5/14; G01N33/564; G01N33/76
Domestic Patent References:
| WO1991009137A1 | 1991-06-27 |
Foreign References:
| JP2021103947A | 2021-07-26 |
Other References:
NEUMANN SUSANNE ET AL: "Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice", vol. 106, no. 30, 28 July 2009 (2009-07-28), pages 12471 - 12476, XP055929513, ISSN: 0027-8424, Retrieved from the Internet DOI: 10.1073/pnas.0904506106
MCINTOSH L.M. ET AL: "Hypothyroidism prolongs and increases mdx muscle precursor proliferation and delays myotube formation in normal and dystrophic limb muscle", vol. 73, no. 3-4, 1 March 1995 (1995-03-01), CA, pages 181 - 190, XP055929874, ISSN: 0829-8211, Retrieved from the Internet DOI: 10.1139/o95-022
MCINTOSH L.M. ET AL: "Hypothyroidism prolongs and increases mdx muscle precursor proliferation and delays myotube formation in normal and dystrophic limb muscle", vol. 73, no. 3-4, 1 March 1995 (1995-03-01), CA, pages 181 - 190, XP055929874, ISSN: 0829-8211, Retrieved from the Internet
Attorney, Agent or Firm:
AXE PI (FR)
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