Title:
PROBE FOR DIAGNOSIS OF CONFORMATIONAL DISEASE
Document Type and Number:
WIPO Patent Application WO/2007/074786
Kind Code:
A1
Abstract:
Disclosed are: a probe compound useful for the early diagnosis of a conformational disease; a composition or kit for diagnosis of a conformational disease comprising the probe compound; a therapeutic and/or prophylactic composition for a conformational disease; and others.
Inventors:
KUDO YUKITSUKA (JP)
ARAI HIROYUKI (JP)
OKAMURA NOBUYUKI (JP)
MARUYAMA MASAHIRO (JP)
FURUMOTO SYOZO (JP)
DOH-URA KATSUMI (JP)
ARAI HIROYUKI (JP)
OKAMURA NOBUYUKI (JP)
MARUYAMA MASAHIRO (JP)
FURUMOTO SYOZO (JP)
DOH-URA KATSUMI (JP)
Application Number:
PCT/JP2006/325804
Publication Date:
July 05, 2007
Filing Date:
December 25, 2006
Export Citation:
Assignee:
UNIV TOHOKU (JP)
KUDO YUKITSUKA (JP)
ARAI HIROYUKI (JP)
OKAMURA NOBUYUKI (JP)
MARUYAMA MASAHIRO (JP)
FURUMOTO SYOZO (JP)
DOH-URA KATSUMI (JP)
KUDO YUKITSUKA (JP)
ARAI HIROYUKI (JP)
OKAMURA NOBUYUKI (JP)
MARUYAMA MASAHIRO (JP)
FURUMOTO SYOZO (JP)
DOH-URA KATSUMI (JP)
International Classes:
C07D277/84; A61K31/4245; A61K31/4439; A61K31/5377; A61K51/00; A61P25/14; A61P25/16; A61P25/28; C07D401/06; C07D405/06; C07D413/04; C07D417/06
Domestic Patent References:
| WO2004035522A1 | 2004-04-29 | |||
| WO1997026919A2 | 1997-07-31 |
Foreign References:
| JP2004067659A | 2004-03-04 | |||
| JPH06194780A | 1994-07-15 | |||
| JP2004525800A | 2004-08-26 | |||
| JP2004534344A | 2004-11-11 |
Other References:
SHIMADZU H. ET AL.: "Novel probes for imaging amyloid-beta: F-18 and C-11 labeling of 2-(4-aminostyryl)benzoxazole derivatives", J. LABEL COMPD. RADIOPHARM., vol. 47, 2004, pages 181 - 190, XP003015009
OKAMURA N. ET AL.: "Styrylbenzoxazole Derivatives for In Vivo Imaging of Amyloid Plaques in the Brain", THE JOURNAL OF NEUROSCIENCE, vol. 24, no. 10, 10 March 2004 (2004-03-10), pages 2535 - 2541, XP003015010
OKAMURA N. ET AL.: "Quinoline and Benzimidazole Derivatives: Candidate Probes for In Vivo Imaging of Tau Pathology in Alzheimer's Disease", THE JOURNAL OF NEUROSCIENCE, vol. 25, no. 47, 23 November 2005 (2005-11-23), pages 10857 - 10862, XP003015011
STETINOVA J. ET AL.: "2-(benzoxazole-2-yl)-3-heteroarylprop-2-enenitrile", CHEM. PAPERS, vol. 51, no. 6B, 1997, pages 390 - 394, XP003015012
ISHIKAWA K. ET AL.: "Styrylbenzoazole derivatives for imaging of prion plaques and treatment of transmissible spongiform encephalopathies", JOURNAL OF NEUROCHEMISTRY, vol. 99, 2006, pages 198 - 205, XP003015013
See also references of EP 1967517A4
OKAMURA N. ET AL.: "Styrylbenzoxazole Derivatives for In Vivo Imaging of Amyloid Plaques in the Brain", THE JOURNAL OF NEUROSCIENCE, vol. 24, no. 10, 10 March 2004 (2004-03-10), pages 2535 - 2541, XP003015010
OKAMURA N. ET AL.: "Quinoline and Benzimidazole Derivatives: Candidate Probes for In Vivo Imaging of Tau Pathology in Alzheimer's Disease", THE JOURNAL OF NEUROSCIENCE, vol. 25, no. 47, 23 November 2005 (2005-11-23), pages 10857 - 10862, XP003015011
STETINOVA J. ET AL.: "2-(benzoxazole-2-yl)-3-heteroarylprop-2-enenitrile", CHEM. PAPERS, vol. 51, no. 6B, 1997, pages 390 - 394, XP003015012
ISHIKAWA K. ET AL.: "Styrylbenzoazole derivatives for imaging of prion plaques and treatment of transmissible spongiform encephalopathies", JOURNAL OF NEUROCHEMISTRY, vol. 99, 2006, pages 198 - 205, XP003015013
See also references of EP 1967517A4
Attorney, Agent or Firm:
TANAKA, Mitsuo et al. (IMP Building 3-7, Shiromi 1-chome, Chuo-ku, Osaka-sh, Osaka 01, JP)
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