Title:
PROCESS FOR THE PREPARATION OF POLYMORPHS OF SELECTIVE SEROTONIN REUPTAKE INHIBITOR
Document Type and Number:
WIPO Patent Application WO2005047229
Kind Code:
A3
Abstract:
The present invention is directed to Form II, III, IV and V of sertraline hydrochloride and methods for its preparation. According to the present invention, the various polymorphs of sertraline hydrochloride may be produced either, directly from sertraline base or sertraline acetate.
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Inventors:
RAO DHARMARAJ RAMACHANDRA (IN)
KANKAN RAJENDRA NARAYANRAO (IN)
KANKAN RAJENDRA NARAYANRAO (IN)
Application Number:
PCT/GB2004/004672
Publication Date:
July 07, 2005
Filing Date:
November 04, 2004
Export Citation:
Assignee:
CIPLA LTD (IN)
RAO DHARMARAJ RAMACHANDRA (IN)
KANKAN RAJENDRA NARAYANRAO (IN)
WAIN CHRISTOPHER PAUL (GB)
RAO DHARMARAJ RAMACHANDRA (IN)
KANKAN RAJENDRA NARAYANRAO (IN)
WAIN CHRISTOPHER PAUL (GB)
International Classes:
C07C209/84; C07C211/42; (IPC1-7): C07C209/84; C07C211/42; A61K31/135
Domestic Patent References:
| WO2001032601A1 | 2001-05-10 | |||
| WO2001045692A1 | 2001-06-28 | |||
| WO2003093217A1 | 2003-11-13 |
Foreign References:
| US5248699A | 1993-09-28 | |||
| US6495721B1 | 2002-12-17 | |||
| US6500987B1 | 2002-12-31 | |||
| US6517866B1 | 2003-02-11 |
Other References:
ALMARSSON O ET AL: "High-Throughput Surveys of Crystal Form Diversity of Highly Polymorphic Pharmaceutical Compounds", CRYSTAL GROWTH & DESIGN, ACS, WASHINGTON, DC, US, vol. 3, no. 6, 2003, pages 927 - 933, XP002295000, ISSN: 1528-7483
HALEBLIAN J K: "CHARACTERIZATION OF HABITS AND CRYSTALLINE MODIFICATION OF SOLIDS AND THEIR PHARMACEUTICAL APPLICATIONS", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 64, no. 8, August 1975 (1975-08-01), pages 1269, XP009031935, ISSN: 0022-3549
REMENAR J F ET AL: "Salt Selection and Simultaneous Polymorphism Assessment via High Throughput Crystallization: The Case of Sertraline", ORGANIC PROCESS RESEARCH AND DEVELOPMENT, CAMBRIDGE, GB, vol. 7, no. 6, 14 October 2003 (2003-10-14), pages 990 - 996, XP002277129
HALEBLIAN J K: "CHARACTERIZATION OF HABITS AND CRYSTALLINE MODIFICATION OF SOLIDS AND THEIR PHARMACEUTICAL APPLICATIONS", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN PHARMACEUTICAL ASSOCIATION. WASHINGTON, US, vol. 64, no. 8, August 1975 (1975-08-01), pages 1269, XP009031935, ISSN: 0022-3549
REMENAR J F ET AL: "Salt Selection and Simultaneous Polymorphism Assessment via High Throughput Crystallization: The Case of Sertraline", ORGANIC PROCESS RESEARCH AND DEVELOPMENT, CAMBRIDGE, GB, vol. 7, no. 6, 14 October 2003 (2003-10-14), pages 990 - 996, XP002277129
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