Title:
PROCESS FOR PRODUCING L-LYSINE
Document Type and Number:
WIPO Patent Application WO/1996/040934
Kind Code:
A1
Abstract:
L-Lysine productivity and production rate are improved by sustaining in corynebacteria the aspartokinase wherein the feedback inhibition by L-lysine and L-threonine has been substantially remitted and successively potentiating a DNA encoding dihydrodipicolinate reductase, a DNA encoding dihydrodipicolinate synthetase, a DNA encoding diaminopimelate decarboxylase and a DNA encoding diaminopimelate dehydrogenase.
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Inventors:
OTSUNA SEIKO (JP)
SUGIMOTO MASAKAZU (JP)
IZUI MASAKO (JP)
HAYAKAWA ATSUSHI (JP)
NAKANO EIICHI (JP)
KOBAYASHI MASAKI (JP)
YOSHIHARA YASUHIKO (JP)
NAKAMATSU TSUYOSHI (JP)
SUGIMOTO MASAKAZU (JP)
IZUI MASAKO (JP)
HAYAKAWA ATSUSHI (JP)
NAKANO EIICHI (JP)
KOBAYASHI MASAKI (JP)
YOSHIHARA YASUHIKO (JP)
NAKAMATSU TSUYOSHI (JP)
Application Number:
PCT/JP1996/001511
Publication Date:
December 19, 1996
Filing Date:
June 05, 1996
Export Citation:
Assignee:
AJINOMOTO KK (JP)
OTSUNA SEIKO (JP)
SUGIMOTO MASAKAZU (JP)
IZUI MASAKO (JP)
HAYAKAWA ATSUSHI (JP)
NAKANO EIICHI (JP)
KOBAYASHI MASAKI (JP)
YOSHIHARA YASUHIKO (JP)
NAKAMATSU TSUYOSHI (JP)
OTSUNA SEIKO (JP)
SUGIMOTO MASAKAZU (JP)
IZUI MASAKO (JP)
HAYAKAWA ATSUSHI (JP)
NAKANO EIICHI (JP)
KOBAYASHI MASAKI (JP)
YOSHIHARA YASUHIKO (JP)
NAKAMATSU TSUYOSHI (JP)
International Classes:
C12N1/21; C12N9/06; C12N9/12; C12N9/88; C12N15/31; C12N15/52; C12N15/77; C12P13/08; C12P19/34; C12R1/15; (IPC1-7): C12N15/52; C12N1/21; C12P13/08
Foreign References:
| JPH0775578A | 1995-03-20 |
Other References:
CREMER J., EGGELING L., SAHM H.: "CONTROL OF THE LYSINE BIOSYNTHESIS SEQUENCE IN CORYNEBACTERIUM GLUTAMICUM AS ANALYZED BY OVEREXPRESSION OF THE INDIVIDUAL CORRESPONDING GENES.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 57., no. 06., 1 June 1991 (1991-06-01), US, pages 1746 - 1752., XP000616281, ISSN: 0099-2240
ISHINO S, ET AL.: "NUCLEOTIDE SEQUENCE O THE MESO-DIAMINOPIMELATE D-DEHYDROGENASE GENEFROM CORYNEBACTERIUM GLUTAMICUM", NUCLEIC ACIDS RESEARCH, INFORMATION RETRIEVAL LTD., GB, vol. 15, no. 09, 1 January 1987 (1987-01-01), GB, pages 3917, XP001056569, ISSN: 0305-1048, DOI: 10.1093/nar/15.9.3917
MARCEL T, ET AL.: "NUCLEOTIDE SEQUENCE AND ORGANIZATION OF THE UPSTREAM REGION OF THE CORYNEBACTERIUM GLUTAMICUM LYSA GENE", MOLECULAR MICROBIOLOGY., WILEY-BLACKWELL PUBLISHING LTD, GB, vol. 04, no. 11, 1 January 1990 (1990-01-01), GB, pages 1819 - 1830, XP008057478, ISSN: 0950-382X, DOI: 10.1111/j.1365-2958.1990.tb02030.x
YEH P, SICARD A M, SINSKEY A J: "NUCLEOTIDE SEQUENCE OF THE LYSA GENE OF CORYNEBACTERIUM GLUTAMICUM AND POSSIBLE MECHANISMS FOR MODULATION OF ITS EXPRESSION", MOLECULAR AND GENERAL GENETICS., SPRINGER VERLAG, BERLIN., DE, vol. 212, no. 01, 1 January 1988 (1988-01-01), DE, pages 112 - 119, XP001002987, ISSN: 0026-8925, DOI: 10.1007/BF00322452
See also references of EP 0841395A1
ISHINO S, ET AL.: "NUCLEOTIDE SEQUENCE O THE MESO-DIAMINOPIMELATE D-DEHYDROGENASE GENEFROM CORYNEBACTERIUM GLUTAMICUM", NUCLEIC ACIDS RESEARCH, INFORMATION RETRIEVAL LTD., GB, vol. 15, no. 09, 1 January 1987 (1987-01-01), GB, pages 3917, XP001056569, ISSN: 0305-1048, DOI: 10.1093/nar/15.9.3917
MARCEL T, ET AL.: "NUCLEOTIDE SEQUENCE AND ORGANIZATION OF THE UPSTREAM REGION OF THE CORYNEBACTERIUM GLUTAMICUM LYSA GENE", MOLECULAR MICROBIOLOGY., WILEY-BLACKWELL PUBLISHING LTD, GB, vol. 04, no. 11, 1 January 1990 (1990-01-01), GB, pages 1819 - 1830, XP008057478, ISSN: 0950-382X, DOI: 10.1111/j.1365-2958.1990.tb02030.x
YEH P, SICARD A M, SINSKEY A J: "NUCLEOTIDE SEQUENCE OF THE LYSA GENE OF CORYNEBACTERIUM GLUTAMICUM AND POSSIBLE MECHANISMS FOR MODULATION OF ITS EXPRESSION", MOLECULAR AND GENERAL GENETICS., SPRINGER VERLAG, BERLIN., DE, vol. 212, no. 01, 1 January 1988 (1988-01-01), DE, pages 112 - 119, XP001002987, ISSN: 0026-8925, DOI: 10.1007/BF00322452
See also references of EP 0841395A1
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