Title:
PRODUCTION OF RECOMBINANT AAV USING ADENOVIRUS COMPRISING AAV REP/CAP GENES
Document Type and Number:
WIPO Patent Application WO2001025462
Kind Code:
A9
Abstract:
This invention relates to novel adenoviruses useful in the production of high titers of recombinant adeno-associated virus (rAAV) comprising a foreign DNA insert and methods of making these adenoviruses. The adenovirus comprises the AAV rep gene in which the p5 promoter of rep is replaced by a minimal promoter or by no promoter. The invention also provides methods of producing high levels of rAAV as a substantially homogeneous preparation and compositions of rAAV.
Inventors:
CHEN HAIFENG (US)
KURTZMAN GARY (US)
KURTZMAN GARY (US)
Application Number:
PCT/US2000/026948
Publication Date:
November 21, 2002
Filing Date:
September 29, 2000
Export Citation:
Assignee:
GENOVO INC (US)
CHEN HAIFENG (US)
KURTZMAN GARY (US)
CHEN HAIFENG (US)
KURTZMAN GARY (US)
International Classes:
C12N15/09; A61K35/76; A61K48/00; C12N7/00; C12N15/861; C12N15/864; A61K39/00; C12R1/91; (IPC1-7): C12N15/86; A61K39/12; A61K48/00
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