Title:
PROPHYLACTIC OR THERAPEUTIC AGENT FOR ACUTE KIDNEY INJURY INDUCED BY ANTICANCER AGENT
Document Type and Number:
WIPO Patent Application WO/2024/111404
Kind Code:
A1
Abstract:
Disclosed is a prophylactic or therapeutic agent that is for acute kidney injury induced by an anticancer agent and that contains at least one selected from the group consisting of: glutathione trisulfide and pharmacologically acceptable salts thereof; at least one cyclodextrin inclusion complex selected from the group consisting of lipoic acid trisulfide, derivatives of the same, and pharmacologically acceptable salts thereof; lipoic acid trisulfide and derivatives thereof; and pantethine trisulfide and pharmacologically acceptable salts thereof. The present invention also discloses a method for determining, on the basis of a blood GDF-15 level, at least one of the dosage, the dosage regimen, and the administration feasibility of the prophylactic or therapeutic agent.
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Inventors:
OHSHIMA ETSUO (JP)
ISHIMA YU (JP)
ISHIMA YU (JP)
Application Number:
PCT/JP2023/040110
Publication Date:
May 30, 2024
Filing Date:
November 07, 2023
Export Citation:
Assignee:
KYOWA HAKKO BIO CO LTD (JP)
UNIV TOKUSHIMA (JP)
UNIV TOKUSHIMA (JP)
International Classes:
A61K31/16; A61K31/385; A61K38/08; A61K47/40; A61P13/12
Domestic Patent References:
| WO2022072925A1 | 2022-04-07 | |||
| WO2022045212A1 | 2022-03-03 | |||
| WO2022045052A1 | 2022-03-03 |
Foreign References:
| JP2022166333A | 2022-11-02 | |||
| JP2022532187A | 2022-07-13 | |||
| JP2006506327A | 2006-02-23 | |||
| JPH01203334A | 1989-08-16 |
Other References:
RE DI F., ET AL.: "EFFICACY AND SAFETY OF HIGH-DOSE CISPLATIN AND CYCLOPHOSPHAMIDE WITH GLUTATHIONE PROTECTION IN THE TREATMENT OF BULKY ADVANCED EPITHELIAL OVARIAN CANCER.", CANCER CHEMOTHERAPY AND PHARMACOLOGY, SPRINGER VERLAG , BERLIN, DE, vol. 25., no. 05., 1 January 1990 (1990-01-01), DE , pages 355 - 360., XP000645591, ISSN: 0344-5704, DOI: 10.1007/BF00686237
KHALIFA EMAN ALY, NABIL AHMED AHMED; HASHEM KHALID SHAABAN; ALLAH AHMAD GAD: "Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity", INTERNATIONAL JOURNAL OF INFLAMMATION, SAGE-HINDAWI ACCESS TO RESEARCH, vol. 2020, 9 April 2020 (2020-04-09), pages 1 - 11, XP093173732, ISSN: 2090-8040, DOI: 10.1155/2020/5369797
JIANG XIAOYAN, ZHU XIAOSONG; LIU NA; XU HONGYA; ZHAO ZHONGXI; LI SIYING; LI SHANZHONG; CAI JIANHUA; CAO JIMIN: "Diallyl Trisulfide Inhibits Growth of NCI-H460 in Vitro and in Vivo , and Ameliorates Cisplatin-Induced Oxidative Injury in the Treatment of Lung Carcinoma in Xenograft Mice", INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, IVYSPRING INTERNATIONAL PUBLISHER, vol. 13, no. 2, 1 January 2017 (2017-01-01), pages 167 - 178, XP093173735, ISSN: 1449-2288, DOI: 10.7150/ijbs.16828
KHALIFA EMAN ALY, NABIL AHMED AHMED; HASHEM KHALID SHAABAN; ALLAH AHMAD GAD: "Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity", INTERNATIONAL JOURNAL OF INFLAMMATION, SAGE-HINDAWI ACCESS TO RESEARCH, vol. 2020, 9 April 2020 (2020-04-09), pages 1 - 11, XP093173732, ISSN: 2090-8040, DOI: 10.1155/2020/5369797
JIANG XIAOYAN, ZHU XIAOSONG; LIU NA; XU HONGYA; ZHAO ZHONGXI; LI SIYING; LI SHANZHONG; CAI JIANHUA; CAO JIMIN: "Diallyl Trisulfide Inhibits Growth of NCI-H460 in Vitro and in Vivo , and Ameliorates Cisplatin-Induced Oxidative Injury in the Treatment of Lung Carcinoma in Xenograft Mice", INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, IVYSPRING INTERNATIONAL PUBLISHER, vol. 13, no. 2, 1 January 2017 (2017-01-01), pages 167 - 178, XP093173735, ISSN: 1449-2288, DOI: 10.7150/ijbs.16828
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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