Title:
PROTOZOAN RHOMBOID PROTEINS
Document Type and Number:
WIPO Patent Application WO2004040009
Kind Code:
A3
Abstract:
Protozoan Rhomboid ProteinsThis invention relates to the identification of protozoan Rhomboid proteins that are involved in the invasive processes of protozoan pathogens, such as P. falciparum. Modulation of these Rhomboid proteins may thus be useful in treating protozoan pathogen infection. Methods and means relating to the modulation of protozoan Rhomboid proteins is provided herein.
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Inventors:
FREEMAN MATTHEW (GB)
Application Number:
PCT/GB2003/004711
Publication Date:
July 01, 2004
Filing Date:
November 03, 2003
Export Citation:
Assignee:
MEDICAL RES COUNCIL (GB)
FREEMAN MATTHEW (GB)
FREEMAN MATTHEW (GB)
International Classes:
A61K38/17; C12N9/64; C12Q1/18; C12Q1/37; (IPC1-7): C12Q1/37; C12N9/50
Domestic Patent References:
| WO2002093177A2 | 2002-11-21 |
Foreign References:
| FR2791685A1 | 2000-10-06 |
Other References:
BLACKMAN M J ET AL: "Secondary processing of the Plasmodium falciparum merozoite surface protein-1(MSP1) by a calcium-dependent membrane-bound serine protease: shedding of MSP133 as a noncovalently associated complex with other fragments of the MSP1", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 50, no. 2, 1992, pages 307 - 315, XP000603761, ISSN: 0166-6851
BLACKMAN M J ET AL: "A conserved parasite serine protease processes the Plasmodium falciparum merozoite surface protein-I", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 62, no. 1, November 1993 (1993-11-01), pages 103 - 114, XP000856228, ISSN: 0166-6851
OPITZ CORINNA ET AL: "Intramembrane cleavage of microneme proteins at the surface of the apicomplexan parasite Toxoplasma gondii", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 21, no. 7, 2 April 2002 (2002-04-02), pages 1577 - 1585, XP002276565, ISSN: 0261-4189
CARRUTHERS VERN B ET AL: "The Toxoplasma adhesive protein MIC2 is proteolytically processed at multiple sites by two parasite-derived proteases", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 19, 12 May 2000 (2000-05-12), pages 14346 - 14353, XP002276566, ISSN: 0021-9258
URBAN SINISA ET AL: "Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic Rhomboids", CURRENT BIOLOGY, vol. 12, no. 17, 3 September 2002 (2002-09-03), pages 1507 - 1512, XP002245174, ISSN: 0960-9822
URBAN S ET AL: "Intramembrane proteolysis controls diverse signalling pathways throughout evolution", CURRENT OPINION IN GENETICS & DEVELOPMENT, CURRENT BIOLOGY LTD, XX, vol. 12, no. 5, 1 October 2002 (2002-10-01), pages 512 - 518, XP002245175, ISSN: 0959-437X
KOONIN EUGENE V ET AL: "The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers.", GENOME BIOLOGY ENGLAND 2003, vol. 4, no. 3, 28 February 2003 (2003-02-28), pages R19, XP002276564, ISSN: 1465-6914
URBAN SINISA ET AL: "Substrate specificity of Rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain.", MOLECULAR CELL, vol. 11, no. 6, June 2003 (2003-06-01), pages 1425 - 1434, XP009022588, ISSN: 1097-2765 (ISSN print)
BLACKMAN M J ET AL: "A conserved parasite serine protease processes the Plasmodium falciparum merozoite surface protein-I", MOLECULAR AND BIOCHEMICAL PARASITOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 62, no. 1, November 1993 (1993-11-01), pages 103 - 114, XP000856228, ISSN: 0166-6851
OPITZ CORINNA ET AL: "Intramembrane cleavage of microneme proteins at the surface of the apicomplexan parasite Toxoplasma gondii", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 21, no. 7, 2 April 2002 (2002-04-02), pages 1577 - 1585, XP002276565, ISSN: 0261-4189
CARRUTHERS VERN B ET AL: "The Toxoplasma adhesive protein MIC2 is proteolytically processed at multiple sites by two parasite-derived proteases", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 19, 12 May 2000 (2000-05-12), pages 14346 - 14353, XP002276566, ISSN: 0021-9258
URBAN SINISA ET AL: "Conservation of intramembrane proteolytic activity and substrate specificity in prokaryotic and eukaryotic Rhomboids", CURRENT BIOLOGY, vol. 12, no. 17, 3 September 2002 (2002-09-03), pages 1507 - 1512, XP002245174, ISSN: 0960-9822
URBAN S ET AL: "Intramembrane proteolysis controls diverse signalling pathways throughout evolution", CURRENT OPINION IN GENETICS & DEVELOPMENT, CURRENT BIOLOGY LTD, XX, vol. 12, no. 5, 1 October 2002 (2002-10-01), pages 512 - 518, XP002245175, ISSN: 0959-437X
KOONIN EUGENE V ET AL: "The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers.", GENOME BIOLOGY ENGLAND 2003, vol. 4, no. 3, 28 February 2003 (2003-02-28), pages R19, XP002276564, ISSN: 1465-6914
URBAN SINISA ET AL: "Substrate specificity of Rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain.", MOLECULAR CELL, vol. 11, no. 6, June 2003 (2003-06-01), pages 1425 - 1434, XP009022588, ISSN: 1097-2765 (ISSN print)
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