Title:
PSEUDO-TYPE RETROVIRAL VECTORS WITH MODIFIABLE SURFACE CAPSID PROTEINS
Document Type and Number:
WIPO Patent Application WO1999028488
Kind Code:
A3
Abstract:
The invention relates to pseudo-type retroviral vectors with modified surface capsid proteins which are suitable for cell-specific transduction of a selected mammal cell type (cell targeting). The invention also relates to a method for the production of cell-specific pseudo-type retroviral vectors and to the use thereof in gene transfers in selected cells.
Inventors:
CICHUTEK KLAUS (DE)
MERGET-MILLITZER HEIKE (DE)
MERGET-MILLITZER HEIKE (DE)
Application Number:
PCT/DE1998/003542
Publication Date:
August 12, 1999
Filing Date:
November 27, 1998
Export Citation:
Assignee:
BUNDESREPUBLIK DEUTSCHLAND LET (DE)
CICHUTEK KLAUS (DE)
MERGET MILLITZER HEIKE (DE)
CICHUTEK KLAUS (DE)
MERGET MILLITZER HEIKE (DE)
International Classes:
A61K48/00; C07K16/32; C12N5/10; C12N15/83; C12N15/86; C12N15/867; (IPC1-7): C12N15/86; A61K48/00; C12N5/10
Domestic Patent References:
| WO1995023846A1 | 1995-09-08 | |||
| WO1996030504A1 | 1996-10-03 |
Other References:
VALSESIA-WITTMANN S ET AL: "IMPROVEMENT OF RETROVIRAL RETARGETING BY USING AMINO ACID SPACERS BETWEEN AN ADDITIONAL BINDING DOMAIN AND THE N TERMINUS OF MOLONEY MURINE LEUKEMIA VIRUS SU", JOURNAL OF VIROLOGY, vol. 70, no. 3, 1 March 1996 (1996-03-01), pages 2059 - 2064, XP002037488
CHU T-H T & DORNBURG R: "Towars highly efficientcell-type-specific gene transfer with retroviral vectors displaying single-chain antibodies", JOURNAL OF VIROLOGY, vol. 71, no. 1, January 1997 (1997-01-01), AMERICAN SOCIETY FOR MICROBIOLOGY US, pages 720 - 725, XP002104908
SCHNIERLE BS ET AL: "Pseudotyping of murine leukemia virus with the envelope glycoproteins of HIV generates a retroviral vector with specificity of infection for CD4-expressing cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 94, August 1997 (1997-08-01), WASHINGTON US, pages 8640 - 8645, XP002104909
SOMIA N V ET AL: "GENERATION OF TARGETED RETROVIRAL VECTORS BY USING SINGLE-CHAIN VARIABLE FRAGMENT: AN APPROACH TO IN VIVO GENE DELIVERY", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 92, 1 August 1995 (1995-08-01), pages 7570 - 7574, XP000672863
CHU T-H T & DORNBURG R: "Towars highly efficientcell-type-specific gene transfer with retroviral vectors displaying single-chain antibodies", JOURNAL OF VIROLOGY, vol. 71, no. 1, January 1997 (1997-01-01), AMERICAN SOCIETY FOR MICROBIOLOGY US, pages 720 - 725, XP002104908
SCHNIERLE BS ET AL: "Pseudotyping of murine leukemia virus with the envelope glycoproteins of HIV generates a retroviral vector with specificity of infection for CD4-expressing cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 94, August 1997 (1997-08-01), WASHINGTON US, pages 8640 - 8645, XP002104909
SOMIA N V ET AL: "GENERATION OF TARGETED RETROVIRAL VECTORS BY USING SINGLE-CHAIN VARIABLE FRAGMENT: AN APPROACH TO IN VIVO GENE DELIVERY", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 92, 1 August 1995 (1995-08-01), pages 7570 - 7574, XP000672863
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