Title:
CELL-SPECIFIC RETROVIRAL VECTORS WITH ANTIBODY DOMAINS AND METHOD FOR THE PRODUCTION THEREOF FOR SELECTIVE GENE TRANSFER
Document Type and Number:
WIPO Patent Application WO1999028489
Kind Code:
A3
Abstract:
Die Erfindung betrifft zellspezifische retrovirale Vektoren mit Antikörpererkennungsdomänen (scFv), die für die zellspezifische Transduktion eines ausgewählten Säugerzelltyps geeignet sind (Zelltargeting), Verfahren zur Herstellung der zellspezifischen retroviralen Vektoren und ihre Verwendung zur Genübertragung in ausgewählte Zellen. Die Erfindung betrifft ferner retrovirale Verpackungszellen zur Gewinnung der erfindungsgemässen zellspezifischen retroviralen Vektoren.
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Inventors:
CICHUTEK KLAUS (DE)
ENGELSTAEDTER MARTIN (DE)
ENGELSTAEDTER MARTIN (DE)
Application Number:
PCT/DE1998/003543
Publication Date:
July 22, 1999
Filing Date:
November 27, 1998
Export Citation:
Assignee:
BUNDESREPUBLIK DEUTSCHLAND LET (DE)
CICHUTEK KLAUS (DE)
ENGELSTAEDTER MARTIN (DE)
CICHUTEK KLAUS (DE)
ENGELSTAEDTER MARTIN (DE)
International Classes:
A61K48/00; C07K16/28; C12N5/10; C12N15/86; C12N15/867; (IPC1-7): C12N15/86; C12N5/10; A61K48/00
Domestic Patent References:
| WO1995023846A1 | 1995-09-08 | |||
| WO1993001288A1 | 1993-01-21 |
Foreign References:
| EP0104014A2 | 1984-03-28 |
Other References:
CHU T. H. ET AL.: "Toward highly efficient cell-type- specific gene transfer with retroviral vectors displaying single-chain antibodies.", JOURNAL OF VIROLOGY, vol. 71, no. 1, January 1997 (1997-01-01), pages 720 - 725, XP002103150
CHISWELL D. J. ET AL.: "PHAGE ANTIBODIES: WILL NEW 'COLICLONAL' ANTIBODIES REPLACE MONOCLONAL ANTIBODIES?", TRENDS IN BIOTECHNOLOGY, vol. 10, no. 3, 1 March 1992 (1992-03-01), pages 80 - 84, XP000249633
LANG I. M. ET AL.: "Recombinant rabbit Fab with binding activity to type-1 plasminogen activator inhibitor derived from a phage-display library against human alpha-granules", GENE, vol. 172, no. 2, 26 June 1996 (1996-06-26), pages 295 - 298, XP002103151
JIANG A. ET AL.: "Cell-type-specific gene transfer into human cells with retroviral vectors that display single-chain antibodies.", JOURNAL OF VIROLOGY, vol. 72, no. 12, December 1998 (1998-12-01), pages 10148 - 10156, XP002103152
CHISWELL D. J. ET AL.: "PHAGE ANTIBODIES: WILL NEW 'COLICLONAL' ANTIBODIES REPLACE MONOCLONAL ANTIBODIES?", TRENDS IN BIOTECHNOLOGY, vol. 10, no. 3, 1 March 1992 (1992-03-01), pages 80 - 84, XP000249633
LANG I. M. ET AL.: "Recombinant rabbit Fab with binding activity to type-1 plasminogen activator inhibitor derived from a phage-display library against human alpha-granules", GENE, vol. 172, no. 2, 26 June 1996 (1996-06-26), pages 295 - 298, XP002103151
JIANG A. ET AL.: "Cell-type-specific gene transfer into human cells with retroviral vectors that display single-chain antibodies.", JOURNAL OF VIROLOGY, vol. 72, no. 12, December 1998 (1998-12-01), pages 10148 - 10156, XP002103152
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