PURIFIED COMPOSITION OF BISPECIFIC MOLECULES AND METHODS OF PRODUCTION

WIPO Patent Application WO2003095626

A3

The invention provides a method for producing purified compositions of bispecific molecules each comprising (a) an antigen recognition portion that binds a Cab-like receptor and (b) one or more double-stranded DNA molecules cross-linked to the antigen recognition portion. In particular, the invention provides a method for purifying bispecific molecules using alcohol precipitation. The invention also relates to the purified products of bispecific molecules. The purified compositions of the invention are useful for treating Systemic Lupus Erythematosus (SLE).

PORTER JAMES P (US)
EBELLE ROSE (US)
CASEY LESLIE (US)
LUKACHER NADYA (US)

PCT/US2003/015360

September 15, 2005

May 13, 2003

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ELUSYS THERAPEUTICS INC (US)
PORTER JAMES P (US)
EBELLE ROSE (US)
CASEY LESLIE (US)
LUKACHER NADYA (US)

A61K31/7088; A61K47/48; C07K16/28; C07K16/44; (IPC1-7): C07K16/00; C12P21/08

WO2002075275A2	2002-09-26
WO2003026490A2	2003-04-03
WO2003007971A1	2003-01-30

US5879679A

1999-03-09

CRAIG M.L ET AL: "Clearance of anti-double-stranded DNA antibodies", ARTHRITIS AND RHEUMATISM, vol. 43, no. 10, October 2000 (2000-10-01), pages 2265 - 2275, XP002988647
PINCUS S.E. ET AL: "Evaluation of Antigen-based Heteropolymer for Treatment of Systemic Lupus Erythematosus in a Nonhuman Primate Model", CLINICAL IMMUNOLOGY, vol. 105, no. 2, 2002, pages 141 - 154, XP002988648

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