Title:
METHOD FOR CYTOPROTECTION THROUGH MDM2 AND HDM2 INHIBITION
Document Type and Number:
WIPO Patent Application WO2003095625
Kind Code:
A3
Abstract:
The present invention is directed to a method of protecting one or more cells from programmed cytotoxic cell death by contacting the cells with a cytoprotective amount of an MDM2 and/or HDM2 inhibitor. The cytoprotective amount of inhibitor is typically used as a pulsed administration. Useful inhibitors include a class of 1,4-benzodiazepines, which act as inhibitors of MDM2-p53 interactions. The method of the invention can be employed as an adjunct to chemotherapy or radiation therapy. In addition, the methods of the invention can be employed to treat a disease or condition that involves excessive cell death.
Inventors:
KOBLISH HOLLY K (US)
MANTHEY CARL L (US)
MOLLOY CHRISTOPHER J (US)
MANTHEY CARL L (US)
MOLLOY CHRISTOPHER J (US)
Application Number:
PCT/US2003/014923
Publication Date:
July 15, 2004
Filing Date:
May 13, 2003
Export Citation:
Assignee:
DIMENSIONAL PHARM INC (US)
KOBLISH HOLLY K (US)
MANTHEY CARL L (US)
MOLLOY CHRISTOPHER J (US)
KOBLISH HOLLY K (US)
MANTHEY CARL L (US)
MOLLOY CHRISTOPHER J (US)
International Classes:
A61K31/5513; (IPC1-7): A61K31/55
Foreign References:
| US5702908A | 1997-12-30 |
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