LIVER INFLAMMATION PREDICTIVE GENES - PHASE 1 MOLECULAR TOXICOLOGY I

Title:

LIVER INFLAMMATION PREDICTIVE GENES

Document Type and Number:

WIPO Patent Application WO2003095624

Kind Code:

B1

Abstract:

The invention provides toxicity predictive genes that can be used to predict toxicity in response to one more agents. The invention provides for a method of predicting the liver toxicity In Vivo or In Vitro to an agent. The method comprises obtaining a biological sample from an individual, cell culture or explant treated with the agent. The expression of one or more liver toxicity predictive genes in the sample is measured, wherein the genes are selected from a group consisting of partial gene sequences of genes identified as responsive to agents causing liver inflammation. The process generates a test expression profile. The test expression profile is used with a set of reference expression profiles in a Predictive Model to determine whether the agent will induce liver toxicity in the individual.

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Inventors:

KIER LARRY
NOLAN TIMOTHY D
SANKAR USHA
DERBEL MAHER

Application Number:

PCT/US2003/014832

Publication Date:

February 03, 2005

Filing Date:

May 09, 2003

Export Citation:

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Assignee:

PHASE 1 MOLECULAR TOXICOLOGY I (US)

International Classes:

G16B20/00; C12Q1/68; G01N33/48; G01N33/50; G06F7/00; G06G7/48; G16B25/10; G16B40/20; G16B40/30; C12N; (IPC1-7): G01N33/48; G01N33/50; C12Q1/68; G06F7/00; G06G7/48

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