Title:
PYRROLIDINE AND PIPERIDINE DERIVATIVES AS FACTOR XA INHIBITORS
Document Type and Number:
WIPO Patent Application WO2005032472
Kind Code:
A3
Abstract:
The present application describes pyrrolidine and piperidine derivatives or pharmaceutically acceptable salt forms thereof. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
Inventors:
SHI YAN (US)
STEIN PHILIP D (US)
HAN WEI (US)
GUNGOR TIMUR (US)
STEIN PHILIP D (US)
HAN WEI (US)
GUNGOR TIMUR (US)
Application Number:
PCT/US2004/032010
Publication Date:
August 11, 2005
Filing Date:
September 29, 2004
Export Citation:
Assignee:
BRISTOL MYERS SQUIBB CO (US)
SHI YAN (US)
STEIN PHILIP D (US)
HAN WEI (US)
GUNGOR TIMUR (US)
SHI YAN (US)
STEIN PHILIP D (US)
HAN WEI (US)
GUNGOR TIMUR (US)
International Classes:
A61K31/40; A61K31/404; A61K31/41; A61K31/421; A61K31/44; A61K31/4427; A61K31/454; A61K31/498; A61K31/502; A61K31/517; C07D401/14; A61K; (IPC1-7): A61K31/40; A61K31/41; A61K31/44; A61K31/404; A61K31/421; A61K31/441; A61K31/4427; C07D401/14
Other References:
DATABASE CA [online] KOBAYASHI ET AL: "Heterocyclic sulfonyl compounds and activated blood coagulation factor X inhibitors contein them.", XP002989453, Database accession no. (135:313616)
DATABASE CA GRECO ET AL: "Preparation of (N-strylsulfonyl pyrrolidinyl carbamoyl phenyl guianidines) and analogs as serine protease in hibitors.", XP002989454
DATABASE CA BEIGHT ET AL: "Preparation of pyrrole factor Xa inhibitors as antithrombotic agents.", XP002989455
DATABASE CA GRECO ET AL: "Preparation of (N-strylsulfonyl pyrrolidinyl carbamoyl phenyl guianidines) and analogs as serine protease in hibitors.", XP002989454
DATABASE CA BEIGHT ET AL: "Preparation of pyrrole factor Xa inhibitors as antithrombotic agents.", XP002989455
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