Title:
RADIATION SENSITIZING AGENT
Document Type and Number:
WIPO Patent Application WO/2012/147834
Kind Code:
A1
Abstract:
[Problem] The purpose of the present invention is to provide a radiation sensitizing agent which can increase the radiation sensitivity of tumor cells in a radiation therapy while protecting normal cells.
[Solution] The purpose can be achieved by a radiation sensitizing agent which contains ascorbic acid, a pharmaceutically acceptable salt of ascorbic acid, or a pharmaceutically acceptable solvate of ascorbic acid as an active ingredient. For example, the administration of the radiation sensitizing agent is started 1 to 2 hours inclusive before the initiation of the irradiation with radioactive ray, is halted during the irradiation with radioactive ray, and is resumed for 10 minutes to 2 hours inclusive after the completion of the irradiation with radioactive ray.
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Inventors:
AOKI YUKIMASA (JP)
AOKI HARUHISA (JP)
AOKI HARUHISA (JP)
Application Number:
PCT/JP2012/061178
Publication Date:
November 01, 2012
Filing Date:
April 26, 2012
Export Citation:
Assignee:
AOKI YUKIMASA (JP)
AOKI HARUHISA (JP)
AOKI HARUHISA (JP)
International Classes:
A61K31/375; A61P35/00
Other References:
SHINOZAKI K ET AL.: "Ascorbic Acid Enhances Radiation-induced Apoptosis in an HL60 Human Leukemia Cell Line", JOURNAL OF RADIATION RESEARCH, vol. 52, no. 2, 19 March 2011 (2011-03-19), pages 229 - 237
TAPER HS ET AL.: "Potentiation of radiotherapy by nontoxic pretreatment with combined vitamins C and K3 in mice bearing solid transplantable tumor", ANTICANCER RESEARCH, vol. 16, no. 1, 1996, pages 499 - 503
AL-WAILI NS ET AL.: "A combination of radiotherapy, nitric oxide and a hyperoxygenation sensitizing protocol for brain malignant tumor treatment", MEDICAL HYPOTHESES, vol. 68, no. 3, 2007, pages 528 - 537
MARTIN DF ET AL.: "Enhancement of tumor radiation response by the combination of a perfluorochemical emulsion and hyperbaric oxygen", INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY, BIOLOGY, PHYSICS, vol. 13, no. 5, May 1987 (1987-05-01), pages 747 - 751
KOHSHI K ET AL.: "Radiotherapy after hyperbaric oxygenation for malignant gliomas: a pilot study", JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, vol. 122, no. 11, 1996, pages 676 - 678
TAPER HS ET AL.: "Potentiation of radiotherapy by nontoxic pretreatment with combined vitamins C and K3 in mice bearing solid transplantable tumor", ANTICANCER RESEARCH, vol. 16, no. 1, 1996, pages 499 - 503
AL-WAILI NS ET AL.: "A combination of radiotherapy, nitric oxide and a hyperoxygenation sensitizing protocol for brain malignant tumor treatment", MEDICAL HYPOTHESES, vol. 68, no. 3, 2007, pages 528 - 537
MARTIN DF ET AL.: "Enhancement of tumor radiation response by the combination of a perfluorochemical emulsion and hyperbaric oxygen", INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY, BIOLOGY, PHYSICS, vol. 13, no. 5, May 1987 (1987-05-01), pages 747 - 751
KOHSHI K ET AL.: "Radiotherapy after hyperbaric oxygenation for malignant gliomas: a pilot study", JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, vol. 122, no. 11, 1996, pages 676 - 678
Attorney, Agent or Firm:
HIROSE TAKAYUKI (JP)
Takayuki Hirose (JP)
Takayuki Hirose (JP)
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Claims: