Title:
RATIONAL IDENTIFICATION OF FDA APPROVED DRUGS BY COMPUTATIONAL MODELLING AND INHIBITING RBD/ACE2 BINDING FOR COVID-19 TREATMENT
Document Type and Number:
WIPO Patent Application WO/2022/043816
Kind Code:
A3
Abstract:
The present invention provides 3D bioprinted models for COVID-19 that simulates endothelial dysfunction, viral entry and other associated inflammatory responses caused by the virus and thus can be used for discovering new drugs, repurposing existing drugs used for other indication, testing monoclonal and polyclonal antibodies/passive vaccines with neutralizing properties and other nutraceuticals, herbal products for COVID-19. Using the platform technology of 3D bioprinting applicants have identified Ertugliflozin as a novel candidate for immediate repurposing as a treatment option for COVID-19 infections.
Inventors:
SAXENA UDAY (IN)
VOLETI SREEDHARA RAO (IN)
SAXENA SHALINI (IN)
MALHOTRA NIKHIL (IN)
RATNAKAR PALAKODETI (IN)
VANGALA SUBRAHMANYAM (IN)
VOLETI SREEDHARA RAO (IN)
SAXENA SHALINI (IN)
MALHOTRA NIKHIL (IN)
RATNAKAR PALAKODETI (IN)
VANGALA SUBRAHMANYAM (IN)
Application Number:
PCT/IB2021/057470
Publication Date:
May 05, 2022
Filing Date:
August 13, 2021
Export Citation:
Assignee:
REAGENE INNOVATIONS PVT LTD (IN)
IN SILICO DISCOVERY RES ACADEMIC SERVICES INDRAS PRIVATE LIMITED (IN)
TECH MAHINDRA LTD (IN)
IN SILICO DISCOVERY RES ACADEMIC SERVICES INDRAS PRIVATE LIMITED (IN)
TECH MAHINDRA LTD (IN)
International Classes:
C12N5/07; C12N5/071
Other References:
LANSDOWNE LAURA ELIZABETH: "Using Bioprinted Tissue Models To Test Drugs Against Diseases Including COVID-19", TECHNOLOGY NETWORKS DRUG DISCOVERY - INDUSTRY INSIGHT, TECHNOLOGY NETWORKS, 16 April 2020 (2020-04-16), pages 1 - 4, XP055937945, Retrieved from the Internet [retrieved on 20220704]
HORVĂTH LENKE, UMEHARA YUKI, JUD CORINNE, BLANK FABIAN, PETRI-FINK ALKE, ROTHEN-RUTISHAUSER BARBARA: "Engineering an in vitro air-blood barrier by 3D bioprinting", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 5, no. 1, 1 July 2015 (2015-07-01), US , pages 7974, XP055937952, ISSN: 2045-2322, DOI: 10.1038/srep07974
WANG DAWEI, HU BO, HU CHANG, ZHU FANGFANG, LIU XING, ZHANG JING, WANG BINBIN, XIANG HUI, CHENG ZHENSHUN, XIONG YONG, ZHAO YAN, LI : "Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel CoronavirusâInfected Pneumonia in Wuhan, China", JAMA THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, AMERICAN MEDICAL ASSOCIATION, US, vol. 323, no. 11, 17 March 2020 (2020-03-17), US , pages 1061 - 1069, XP055846945, ISSN: 0098-7484, DOI: 10.1001/jama.2020.1585
HORVĂTH LENKE, UMEHARA YUKI, JUD CORINNE, BLANK FABIAN, PETRI-FINK ALKE, ROTHEN-RUTISHAUSER BARBARA: "Engineering an in vitro air-blood barrier by 3D bioprinting", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, US, vol. 5, no. 1, 1 July 2015 (2015-07-01), US , pages 7974, XP055937952, ISSN: 2045-2322, DOI: 10.1038/srep07974
WANG DAWEI, HU BO, HU CHANG, ZHU FANGFANG, LIU XING, ZHANG JING, WANG BINBIN, XIANG HUI, CHENG ZHENSHUN, XIONG YONG, ZHAO YAN, LI : "Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel CoronavirusâInfected Pneumonia in Wuhan, China", JAMA THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, AMERICAN MEDICAL ASSOCIATION, US, vol. 323, no. 11, 17 March 2020 (2020-03-17), US , pages 1061 - 1069, XP055846945, ISSN: 0098-7484, DOI: 10.1001/jama.2020.1585
Attorney, Agent or Firm:
SANTHANAM, Kausalya (IN)
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