Title:
REMEDY FOR AMYLOID DISEASES AND DRUG FOR MONITORING THE SAME
Document Type and Number:
WIPO Patent Application WO/2007/034757
Kind Code:
A1
Abstract:
A styrylbenzene derivative represented by the following chemical formula (1)
has an effect of inhibiting the coagulation or fibrosis of an amyloid protein:
wherein R1 and R2 independently represent hydroxyl or carboxyl;
and R3 represents fluorine or bromine. Because of being capable of
inhibiting a structural change in an amyloid protein accompanying an amyloid
disease, the above-described styrylbenzene derivative is efficacious in treating
amyloid diseases. In addition, it has an affinity for an amyloid protein and,
therefore, is effective in detecting amyloid proteins. Accordingly, use of
the above compound enables both of the treatment and monitoring of amyloid diseases.
Inventors:
NONAKA HIROMI (JP)
KASE HIROSHI (JP)
KASE HIROSHI (JP)
Application Number:
PCT/JP2006/318420
Publication Date:
March 29, 2007
Filing Date:
September 15, 2006
Export Citation:
Assignee:
FUENCE CO LTD (JP)
NONAKA HIROMI (JP)
KASE HIROSHI (JP)
NONAKA HIROMI (JP)
KASE HIROSHI (JP)
International Classes:
A61K49/00; A61K31/194; A61K45/00; A61P25/00; A61P25/26; A61P25/28
Domestic Patent References:
| WO2005042461A1 | 2005-05-12 |
Other References:
ISHIKAWA K. ET AL.: "Amyloid imaging probes are useful for detection of prion plaques and treatment of transmissible spongiform encephalopathies", THE JOURNAL OF GENERAL VIROLOGY, vol. 85, 2004, pages 1785 - 1790, XP003010836
Attorney, Agent or Firm:
SUGIMURA, Kosaku et al. (2-4 Kasumigaseki 3-chom, Chiyoda-ku Tokyo 13, JP)
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