Title:
REMEDY FOR ANGIOGENESIS-RELATED DISEASE COMPRISING CHONDROMODULIN-I AS THE ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2007/034753
Kind Code:
A1
Abstract:
It is intended to clarify the onset mechanism of a disease caused by angiogenesis
by analyzing the action of an antiangiogenetic factor in the heart valve, etc.
More specifically, it is intended to provide a remedy for an angiogenesis-related
disease such as heart valve disease and a method of efficiently screening this
remedy. It is found out that chondromodulin-I is remarkably expressed in the
heart valve and plays an important role in maintaining the normal functions of
the valve by preventing angiogenesis, thickening and calcification which bring
about heart valve disease. It is expected that the chondromodulin-I protein
or a substance capable of activating the expression or function of this protein
would exert a therapeutic effect on an angiogenesis-related disease.
Inventors:
FUKUDA KEIICHI (JP)
HIRAKI YUJI (JP)
HIRAKI YUJI (JP)
Application Number:
PCT/JP2006/318406
Publication Date:
March 29, 2007
Filing Date:
September 15, 2006
Export Citation:
Assignee:
FUKUDA KEIICHI (JP)
HIRAKI YUJI (JP)
HIRAKI YUJI (JP)
International Classes:
A61K38/00; A01K67/027; A61K31/7088; A61K45/00; A61K48/00; A61P9/00; A61P9/10; A61P27/02; A61P43/00; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; C12N15/09
Domestic Patent References:
| WO2001023557A1 | 2001-04-05 |
Foreign References:
| JP2004123722A | 2004-04-22 | |||
| JP2001299363A | 2001-10-30 |
Other References:
YOSHIOKA M.: "Shinzoben ni Oite Chondromoduin-I ha Kekkan Shinsei o Sogai shi Benkino o Tamotsu", ENSHO SAISEI, vol. 25, no. 4, July 2005 (2005-07-01), pages 331, XP003010831
YOSHIOKA M.: "Chondromodulin-I no Hito Shinzoben ni Okeru Hatsugen", ENSHO SAISEI, vol. 25, no. 4, July 2005 (2005-07-01), pages 332, XP003010832
YOSHIOKA M. ET AL.: "Kekkan Shisei Yokusei Inshi Chondromodulin-I no Shinzo ni Okeru Hatsugen", THE JOURNAL OF JAPANESE COLLEGE OF ANGIOLOGY, vol. 44, no. 9, 2004, pages 442, XP003010833
OSHIMA Y. ET AL.: "Expression and localization of tenomodulin, a transmembrane type chondromodulin-I-related angiogenesis inhibitor, in mouse eyes", INVESTIGATIVE OPHTHALMOLOGY & VIRUSAL SCIENCE, vol. 44, no. 5, 2003, pages 1814 - 1823, XP001181222
HIRAKI Y. ET AL.: "Kekkan Shinnyu Shoheki to shiteno Chondromodulin-I", IGAKU NO AYUMI, vol. 194, no. 10, 2000, pages 775 - 780, XP003010834
NAKAMICHI Y. ET AL.: "Chondromodulin I is a bone remodeling factor", MOLECULAR AND CELLULAR BIOLOGY, vol. 23, no. 2, 2003, pages 636 - 644, XP002411353
SOINI Y. ET AL.: "Angiogenesis is involved in the pathogenesis of nonrheumatic aortic valve stenosis", HUMAN PATHOLOGY, vol. 34, no. 8, 2003, pages 756 - 763, XP003010835
See also references of EP 1946765A4
YOSHIOKA M.: "Chondromodulin-I no Hito Shinzoben ni Okeru Hatsugen", ENSHO SAISEI, vol. 25, no. 4, July 2005 (2005-07-01), pages 332, XP003010832
YOSHIOKA M. ET AL.: "Kekkan Shisei Yokusei Inshi Chondromodulin-I no Shinzo ni Okeru Hatsugen", THE JOURNAL OF JAPANESE COLLEGE OF ANGIOLOGY, vol. 44, no. 9, 2004, pages 442, XP003010833
OSHIMA Y. ET AL.: "Expression and localization of tenomodulin, a transmembrane type chondromodulin-I-related angiogenesis inhibitor, in mouse eyes", INVESTIGATIVE OPHTHALMOLOGY & VIRUSAL SCIENCE, vol. 44, no. 5, 2003, pages 1814 - 1823, XP001181222
HIRAKI Y. ET AL.: "Kekkan Shinnyu Shoheki to shiteno Chondromodulin-I", IGAKU NO AYUMI, vol. 194, no. 10, 2000, pages 775 - 780, XP003010834
NAKAMICHI Y. ET AL.: "Chondromodulin I is a bone remodeling factor", MOLECULAR AND CELLULAR BIOLOGY, vol. 23, no. 2, 2003, pages 636 - 644, XP002411353
SOINI Y. ET AL.: "Angiogenesis is involved in the pathogenesis of nonrheumatic aortic valve stenosis", HUMAN PATHOLOGY, vol. 34, no. 8, 2003, pages 756 - 763, XP003010835
See also references of EP 1946765A4
Attorney, Agent or Firm:
SHIMIZU, Hatsushi et al. (1-1-1 Oroshi-machi, Tsuchiura-sh, Ibaraki 47, JP)
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