Title:
SIGNAL ENHANCER
Document Type and Number:
WIPO Patent Application WO/2016/136850
Kind Code:
A1
Abstract:
[Problem] To provide a signal enhancer that enhances a signal based on reaction between an α1-6 fucose sugar chain and an α1-6 fucose specific lectin bound thereto, a method for using the same, and use of the same. [Solution] A signal enhancer enhances a signal based on reaction between an α1-6 fucose sugar chain and an α1-6 fucose specific lectin bounded thereto, and is characterized by having, as an active ingredient, at least one selected from the group consisting of urea and thiourea. The final concentration of the urea is preferably 1-9 M and the final concentration of the tiourea is 0.1-1.5 M. Since the signal enhancer allows accurate measurement of an α1-6 fucose sugar chain, the signal enhancer is greatly useful in detection and determination of a disease related to an α1-6 fucose sugar chain and in academic study of an α1-6 fucose sugar chain.
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Inventors:
KUSAMA KEN (JP)
KOBAYASHI YUKA (JP)
UENO YASUSHI (JP)
KOBAYASHI YUKA (JP)
UENO YASUSHI (JP)
Application Number:
PCT/JP2016/055541
Publication Date:
September 01, 2016
Filing Date:
February 25, 2016
Export Citation:
Assignee:
J OIL MILLS INC (JP)
International Classes:
G01N33/574
Domestic Patent References:
| WO2011089988A1 | 2011-07-28 | |||
| WO2014046248A1 | 2014-03-27 |
Foreign References:
| JP2010145202A | 2010-07-01 |
Other References:
YUKA KOBAYASHI: "Screening for New Lectins and Their Applications", OYO TOSHITSU KAGAKU, vol. 3, no. 3, 2013, pages 200 - 201, XP008185309
See also references of EP 3199950A4
See also references of EP 3199950A4
Attorney, Agent or Firm:
NAKAJIMA SHINSUKE (JP)
Shinsuke Nakajima (JP)
Shinsuke Nakajima (JP)
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