Title:
SOMATOSTATIN RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2021/065985
Kind Code:
A1
Abstract:
The present invention addresses the problem of demonstrating the existence of a heterodimer of somatostatin receptor subtype 1 (SSTR1) and somatostatin receptor subtype 4 (SSTR4) and providing a method for screening for a factor capable of binding to the heterodimer and the heterodimer that can be used in the screening method. A transformant which has, introduced therein, DNA encoding somatostatin receptor subtype 1 and DNA encoding somatostatin receptor subtype 4 and can express a heterodimer of somatostatin receptor subtype 1 and somatostatin receptor subtype 4. A method for screening for a compound capable of interacting with a heterodimer of somatostatin receptor subtype 1 and somatostatin receptor subtype 4, the method comprising selecting a compound capable of interacting with the heterodimer among from compounds of interest.
Inventors:
SAIDO TAKAOMI (JP)
SAITO TAKASHI (JP)
MATSUBA SHOKO (JP)
TSUBUKI SATOSHI (JP)
MATSUBA YUKIO (JP)
ARAI HIROKI (JP)
MIHIRA NAOMI (JP)
TAKAMURA RISA (JP)
SAITO TAKASHI (JP)
MATSUBA SHOKO (JP)
TSUBUKI SATOSHI (JP)
MATSUBA YUKIO (JP)
ARAI HIROKI (JP)
MIHIRA NAOMI (JP)
TAKAMURA RISA (JP)
Application Number:
PCT/JP2020/037086
Publication Date:
April 08, 2021
Filing Date:
September 30, 2020
Export Citation:
Assignee:
RIKEN BIO CO LTD (JP)
International Classes:
C12N1/15; C07K14/705; C12N1/19; C12N1/21; C12N5/10; C12N15/12; G01N33/15; G01N33/50
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Other References:
ZOU, YI, TAN HAIPING, ZHAO YUANFENG, ZHOU YUAN, CAO LIN: "Expression and selective activation of somatostatin receptor subtypes induces cell cycle arrest in cancer cells", ONCOLOGY LETTERS, vol. 17, 28 November 2018 (2018-11-28), pages 1723 - 1731, XP055811671, DOI: 10.3892/ol.2018.9773
BORROTO-ESCUELA, D. O. ET AL.: "On the G protein-coupled receptor neuromodulation of the claustrum", NEUROCHEMICAL RESEARCH, vol. 45, 6 June 2019 (2019-06-06), pages 5 - 15, XP036978990, DOI: 10.1007/s11064-019-02822-4
IWABUCHI, ERINA: "Detection of estrogen receptor dimers using PLA in cultured breast cancer cells using proximity ligation assay", THE 54TH ANNUAL MEETING OF THE JAPANESE SOCIETY FOR TISSUE CELL CHEMISTRY PROGRAM AND ABSTRACTS, 1 November 2013 (2013-11-01), JP, pages 88, XP009536134
ANONYMOUS: "Reasons why Alzheimer's drug development is not progressing", 23 June 2017 (2017-06-23), Retrieved from the Internet [retrieved on 20201120]
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SAIDOTAKAOMI: "Alzheimer-byo wa Naoseru Yobou Dekiru (phonetic spelling) (Alzheimer's Disease Can Be Cured and Prevented)", 2016, SHUEISHA INC.
NORDBERG ET AL., NEUROBIOLOGY OF AGING, vol. 29, 2008, pages 210 - 221
SOMVANSHI ET AL., CELLULAR SIGNALLING, vol. 21, 2009, pages 1396 - 1414
ZOU ET AL., ONCOLOGY LETTERS, vol. 17, 2019, pages 1723 - 1731
OLIAS ET AL., JOURNAL OF NEUROCHEMISTRY, vol. 89, 2004, pages 1057 - 1091
MOLLER ET AL., BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1616, 2003, pages 1 - 84
DAVIS ET AL., BASIC METHODS IN MOLECULAR BIOLOGY, 1986
SAMBROOK ET AL.: "MOLECULAR CLONING: A LABORATORY MANUAL", 1989, COLD SPRING HARBOR LABORATORY PRESS
SAIDO, AΒ METABOLISM AND ALZHEIMER'S DISEASE, 2003
SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
SAITO ET AL., NAT NEUROSCI, vol. 17, no. 5, 2014, pages 661 - 663
BORROTO-ESCUELA, D. O. ET AL.: "On the G protein-coupled receptor neuromodulation of the claustrum", NEUROCHEMICAL RESEARCH, vol. 45, 6 June 2019 (2019-06-06), pages 5 - 15, XP036978990, DOI: 10.1007/s11064-019-02822-4
IWABUCHI, ERINA: "Detection of estrogen receptor dimers using PLA in cultured breast cancer cells using proximity ligation assay", THE 54TH ANNUAL MEETING OF THE JAPANESE SOCIETY FOR TISSUE CELL CHEMISTRY PROGRAM AND ABSTRACTS, 1 November 2013 (2013-11-01), JP, pages 88, XP009536134
ANONYMOUS: "Reasons why Alzheimer's drug development is not progressing", 23 June 2017 (2017-06-23), Retrieved from the Internet
IWATA N ET AL., NATURE MED, vol. 6, 2000, pages 143 - 151
IWATA N ET AL., SCIENCE, vol. 292, 2001, pages 1550 - 1552
SAIDOTAKAOMI: "Alzheimer-byo wa Naoseru Yobou Dekiru (phonetic spelling) (Alzheimer's Disease Can Be Cured and Prevented)", 2016, SHUEISHA INC.
NORDBERG ET AL., NEUROBIOLOGY OF AGING, vol. 29, 2008, pages 210 - 221
SOMVANSHI ET AL., CELLULAR SIGNALLING, vol. 21, 2009, pages 1396 - 1414
ZOU ET AL., ONCOLOGY LETTERS, vol. 17, 2019, pages 1723 - 1731
OLIAS ET AL., JOURNAL OF NEUROCHEMISTRY, vol. 89, 2004, pages 1057 - 1091
MOLLER ET AL., BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1616, 2003, pages 1 - 84
DAVIS ET AL., BASIC METHODS IN MOLECULAR BIOLOGY, 1986
SAMBROOK ET AL.: "MOLECULAR CLONING: A LABORATORY MANUAL", 1989, COLD SPRING HARBOR LABORATORY PRESS
SAIDO, AΒ METABOLISM AND ALZHEIMER'S DISEASE, 2003
SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
SAITO ET AL., NAT NEUROSCI, vol. 17, no. 5, 2014, pages 661 - 663
Attorney, Agent or Firm:
HIROTA, Masanori (JP)
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