Title:
STABILISED INSULIN COMPOSITIONS
Document Type and Number:
WIPO Patent Application WO2005005477
Kind Code:
A3
Abstract:
The present invention relates to human insulin analogues having a fast onset of action. These analogues may have amino acid in position B26 is substituted with Phe, or be Des(B30) analogues of human insulin. The invention also relates to compositions comprising such insulin analogues, and to compositions comprising a mixture of an insulin analogue having a fast onset of action and insulin having a protracted action.
Inventors:
JONASSEN IB (DK)
HAVELUND SVEN (DK)
KJELDSEN THOMAS BOERGLUND (DK)
RIBEL-MADSEN ULLA (DK)
HAVELUND SVEN (DK)
KJELDSEN THOMAS BOERGLUND (DK)
RIBEL-MADSEN ULLA (DK)
Application Number:
PCT/DK2004/000481
Publication Date:
March 24, 2005
Filing Date:
July 05, 2004
Export Citation:
Assignee:
NOVO NORDISK AS (DK)
JONASSEN IB (DK)
HAVELUND SVEN (DK)
KJELDSEN THOMAS BOERGLUND (DK)
RIBEL-MADSEN ULLA (DK)
JONASSEN IB (DK)
HAVELUND SVEN (DK)
KJELDSEN THOMAS BOERGLUND (DK)
RIBEL-MADSEN ULLA (DK)
International Classes:
A61K38/28; A61P5/50; C07K14/62; (IPC1-7): C07K14/62; A61K38/28; A61P5/50
Domestic Patent References:
| WO2000069901A2 | 2000-11-23 |
Foreign References:
| US5618913A | 1997-04-08 |
Other References:
HU SHI-QUAN ET AL: "Contribution of the B16 and B26 tyrosine residues to the biological activity of insulin", JOURNAL OF PROTEIN CHEMISTRY, vol. 12, no. 6, 1993, pages 741 - 747, XP008041533, ISSN: 0277-8033
MIRMIRA R G ET AL: "IMPORTANCE OF THE CHARACTER AND CONFIGURATION OF RESIDUES B24 B25 AND B26 IN INSULIN-RECEPTOR INTERACTIONS", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 3, 1991, pages 1428 - 1436, XP002313977, ISSN: 0021-9258
KURAPKAT G ET AL: "THE SOLUTION STRUCTURE OF A SUPERPOTENT B-CHAIN-SHORTENED SINGLE-REPLACEMENT INSULIN ANALOGUE", PROTEIN SCIENCE, CAMBRIDGE UNIVERSITY PRESS, CAMBRIDGE, GB, vol. 8, 1999, pages 499 - 508, XP001079187, ISSN: 0961-8368
ZAKOVA LENKA ET AL: "Shortened insulin analogues: Marked changes in biological activity resulting from replacement of TyrB26 and N-methylation of peptide bonds in the C-terminus of the B-chain.", BIOCHEMISTRY, vol. 43, no. 8, 2 March 2004 (2004-03-02), pages 2323 - 2331, XP002313978, ISSN: 0006-2960
XU BIN ET AL: "Diabetes-associated mutations in insulin: Consecutive residues in the B chain contact distinct domains of the insulin receptor", BIOCHEMISTRY, vol. 43, no. 26, 6 July 2004 (2004-07-06), pages 8356 - 8372, XP002313979, ISSN: 0006-2960
ROACH PARIS ET AL: "Clinical pharmacokinetics and pharmacodynamics of insulin lispro mixtures", CLINICAL PHARMACOKINETICS, vol. 41, no. 13, 2002, pages 1043 - 1057, XP008041674, ISSN: 0312-5963
HEINEMANN L ET AL: "Action profile of the rapid acting insulin analogue: human insulin B28Asp.", DIABETIC MEDICINE : A JOURNAL OF THE BRITISH DIABETIC ASSOCIATION. JUL 1993, vol. 10, no. 6, July 1993 (1993-07-01), pages 535 - 539, XP008041638, ISSN: 0742-3071
HELLER SIMON R: "Insulin analogues.", CURRENT MEDICAL RESEARCH AND OPINION. 2002, vol. 18 Suppl 1, 2002, pages s40 - s47, XP002249365, ISSN: 0300-7995
MIRMIRA R G ET AL: "IMPORTANCE OF THE CHARACTER AND CONFIGURATION OF RESIDUES B24 B25 AND B26 IN INSULIN-RECEPTOR INTERACTIONS", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 3, 1991, pages 1428 - 1436, XP002313977, ISSN: 0021-9258
KURAPKAT G ET AL: "THE SOLUTION STRUCTURE OF A SUPERPOTENT B-CHAIN-SHORTENED SINGLE-REPLACEMENT INSULIN ANALOGUE", PROTEIN SCIENCE, CAMBRIDGE UNIVERSITY PRESS, CAMBRIDGE, GB, vol. 8, 1999, pages 499 - 508, XP001079187, ISSN: 0961-8368
ZAKOVA LENKA ET AL: "Shortened insulin analogues: Marked changes in biological activity resulting from replacement of TyrB26 and N-methylation of peptide bonds in the C-terminus of the B-chain.", BIOCHEMISTRY, vol. 43, no. 8, 2 March 2004 (2004-03-02), pages 2323 - 2331, XP002313978, ISSN: 0006-2960
XU BIN ET AL: "Diabetes-associated mutations in insulin: Consecutive residues in the B chain contact distinct domains of the insulin receptor", BIOCHEMISTRY, vol. 43, no. 26, 6 July 2004 (2004-07-06), pages 8356 - 8372, XP002313979, ISSN: 0006-2960
ROACH PARIS ET AL: "Clinical pharmacokinetics and pharmacodynamics of insulin lispro mixtures", CLINICAL PHARMACOKINETICS, vol. 41, no. 13, 2002, pages 1043 - 1057, XP008041674, ISSN: 0312-5963
HEINEMANN L ET AL: "Action profile of the rapid acting insulin analogue: human insulin B28Asp.", DIABETIC MEDICINE : A JOURNAL OF THE BRITISH DIABETIC ASSOCIATION. JUL 1993, vol. 10, no. 6, July 1993 (1993-07-01), pages 535 - 539, XP008041638, ISSN: 0742-3071
HELLER SIMON R: "Insulin analogues.", CURRENT MEDICAL RESEARCH AND OPINION. 2002, vol. 18 Suppl 1, 2002, pages s40 - s47, XP002249365, ISSN: 0300-7995
Download PDF: