Title:
THERAPEUTIC AGENT AND APPLICATION THEREOF IN DRUGS FOR TREATING TUMORS AND/OR CANCER
Document Type and Number:
WIPO Patent Application WO/2018/127052
Kind Code:
A1
Abstract:
The present invention provides a therapeutic agent and an application thereof in drugs for treating tumors and/or cancer. Active ingredients of the therapeutic agent comprise oncolytic viruses that selectively replicate in tumor cells and NK cells.
Inventors:
HU FANG (CN)
CHEN LIN (CN)
ZHAO RONGHUA (CN)
CHEN LIN (CN)
ZHAO RONGHUA (CN)
Application Number:
PCT/CN2018/070166
Publication Date:
July 12, 2018
Filing Date:
January 03, 2018
Export Citation:
Assignee:
HANGZHOU CONVERD CO LTD (CN)
International Classes:
A61K35/768; A61K35/761; A61K35/763; A61K35/765; A61K35/766; A61P35/00
Domestic Patent References:
| WO2016146894A1 | 2016-09-22 |
Foreign References:
| CN105307671A | 2016-02-03 |
Other References:
MCCART, JA ET AL.: "Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes", CANCER RES, vol. 61, 2001, pages 8751 - 8757
SOMANCHI SSLEE DA: "Ex Vivo Expansion of Human NK Cells Using K562 Engineered to Express Membrane Bound IL21", METHODS MOL BIOL, vol. 1441, 2016, pages 175 - 93
PHAN MTLEE SHKIM SKCHO D: "Expansion of NK Cells Using Genetically Engineered K562 Feeder Cells", METHODS MOL BIOL, vol. 1441, 2016, pages 167 - 74
E. KORENV. TORCHILIN, LIFE, vol. 63, 2011, pages 586 - 595
X SONG ET AL., T-CELL ENGAGER-ARMED ONCOLYTIC VACCINIA VIRUS SIGNIFICANTLY ENHANCES ANTITUMOR THERAPYMOLECULAR THERAPY, vol. 22, no. 1, 2014, pages 102 - 111
See also references of EP 3566710A4
SOMANCHI SSLEE DA: "Ex Vivo Expansion of Human NK Cells Using K562 Engineered to Express Membrane Bound IL21", METHODS MOL BIOL, vol. 1441, 2016, pages 175 - 93
PHAN MTLEE SHKIM SKCHO D: "Expansion of NK Cells Using Genetically Engineered K562 Feeder Cells", METHODS MOL BIOL, vol. 1441, 2016, pages 167 - 74
E. KORENV. TORCHILIN, LIFE, vol. 63, 2011, pages 586 - 595
X SONG ET AL., T-CELL ENGAGER-ARMED ONCOLYTIC VACCINIA VIRUS SIGNIFICANTLY ENHANCES ANTITUMOR THERAPYMOLECULAR THERAPY, vol. 22, no. 1, 2014, pages 102 - 111
See also references of EP 3566710A4
Attorney, Agent or Firm:
TEE & HOWE INTELLECTUAL PROPERTY ATTORNEYS (CN)
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