Title:
THERAPEUTIC AGENT COMPRISING ONCOLYTIC VIRUSES AND NK CELLS AND APPLICATION THEREOF IN DRUGS FOR TREATING TUMORS AND/OR CANCER
Document Type and Number:
WIPO Patent Application WO/2018/127053
Kind Code:
A1
Abstract:
Provided are a therapeutic agent comprising oncolytic viruses and NK cells and an application thereof in drugs for treating tumors and/or cancer. Active ingredients of the therapeutic agent comprise oncolytic viruses and NK cells, the oncolytic viruses being capable of selectively replicating in tumor cells.
Inventors:
HU FANG (CN)
CHEN LIN (CN)
ZHAO RONGHUA (CN)
CHEN LIN (CN)
ZHAO RONGHUA (CN)
Application Number:
PCT/CN2018/070172
Publication Date:
July 12, 2018
Filing Date:
January 03, 2018
Export Citation:
Assignee:
HANGZHOU CONVERD CO LTD (CN)
International Classes:
A61K35/768; A61K35/761; A61K35/763; A61K35/765; A61K35/766; A61P35/00; C12N7/00; C12R1/93
Other References:
LI, DANYANG ET AL.: "The Progress of Oncolytic Vaccinia Viruses Modified Genetically for the Tumor Treatment (English Abstrac)", CHINESE JOURNAL OF CELL BIOLOGY, vol. 38, no. 12, 31 December 2016 (2016-12-31), XP055517526, ISSN: 1674-7666
WANG, ZHIHUA: "Research progress of the clinical transplation in NK cells against tumor", CHINESE JOURNAL OF CANCER BIOTHERAPY, vol. 23, no. 3, 30 June 2016 (2016-06-30), pages 419 - 426, XP009515531, ISSN: 1007-385X, DOI: 10.3872/j.issn.1007-385X.2016.03.023
ZHAO, LIMEI: "Rotating Machinery Fault Diagnosis Research Based on Wavelet and Artificial Neural Network", MASTER'S DISSERTATION OF NANKAI UNIVERSITY, 31 May 2014 (2014-05-31), pages 1 - 68, XP009515747
MCCART, JA ET AL.: "Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes", CANCER RES, vol. 61, 2001, pages 8751 - 8757
"Somanchi SS, Lee DA. Ex Vivo Expansion of Human NK Cells Using K562 Engineered to Express Membrane Bound IL21", METHODS MOL BIOL., vol. 1441, 2016, pages 175 - 93
PHAN MTLEE SHKIM SKCHO D: "Expansion of NK Cells Using Genetically Engineered K562 Feeder Cells", METHODS MOL BIOL., vol. 1441, 2016, pages 167 - 74
E. KORENV. TORCHILIN, LIFE, vol. 63, 2011, pages 586 - 595
X SONG ET AL., T-CELL ENGAGER-ARMED ONCOLYTIC VACCINIA VIRUS SIGNIFICANTLY ENHANCES ANTITUMOR THERAPYMOLECULAR THERAPY, vol. 22, no. 1, 2014, pages 102 - 111
See also references of EP 3566709A4
WANG, ZHIHUA: "Research progress of the clinical transplation in NK cells against tumor", CHINESE JOURNAL OF CANCER BIOTHERAPY, vol. 23, no. 3, 30 June 2016 (2016-06-30), pages 419 - 426, XP009515531, ISSN: 1007-385X, DOI: 10.3872/j.issn.1007-385X.2016.03.023
ZHAO, LIMEI: "Rotating Machinery Fault Diagnosis Research Based on Wavelet and Artificial Neural Network", MASTER'S DISSERTATION OF NANKAI UNIVERSITY, 31 May 2014 (2014-05-31), pages 1 - 68, XP009515747
MCCART, JA ET AL.: "Systemic cancer therapy with a tumor-selective vaccinia virus mutant lacking thymidine kinase and vaccinia growth factor genes", CANCER RES, vol. 61, 2001, pages 8751 - 8757
"Somanchi SS, Lee DA. Ex Vivo Expansion of Human NK Cells Using K562 Engineered to Express Membrane Bound IL21", METHODS MOL BIOL., vol. 1441, 2016, pages 175 - 93
PHAN MTLEE SHKIM SKCHO D: "Expansion of NK Cells Using Genetically Engineered K562 Feeder Cells", METHODS MOL BIOL., vol. 1441, 2016, pages 167 - 74
E. KORENV. TORCHILIN, LIFE, vol. 63, 2011, pages 586 - 595
X SONG ET AL., T-CELL ENGAGER-ARMED ONCOLYTIC VACCINIA VIRUS SIGNIFICANTLY ENHANCES ANTITUMOR THERAPYMOLECULAR THERAPY, vol. 22, no. 1, 2014, pages 102 - 111
See also references of EP 3566709A4
Attorney, Agent or Firm:
TEE&HOWE INTELLECTUAL PROPERTY ATTORNEYS (CN)
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