Title:
TOXICITY TEST
Document Type and Number:
WIPO Patent Application WO2003058251
Kind Code:
A3
Abstract:
An in vitro toxicity assay comprising: a) exposing a spheroid sample to a selected concentration of a compound to be assayed; b) incubating the spheroid sample for a suitable period of time; and c) observing if spheroid cell spreading inhibition takes place.
Inventors:
PURCELL WENDY (GB)
XU JINSHENG (GB)
XU JINSHENG (GB)
Application Number:
PCT/GB2003/000097
Publication Date:
November 20, 2003
Filing Date:
January 14, 2003
Export Citation:
Assignee:
UNIV BRISTOL (GB)
PURCELL WENDY (GB)
XU JINSHENG (GB)
PURCELL WENDY (GB)
XU JINSHENG (GB)
International Classes:
C12Q1/02; G01N33/50; G01N33/15; (IPC1-7): G01N33/50
Foreign References:
| EP0105584A1 | 1984-04-18 | |||
| US4889525A | 1989-12-26 |
Other References:
SALES K M ET AL: "AVIAN WHOLE-BRAIN SPHEROID CULTURES: APPLICATIONS IN PESTICIDE TOXICITY", PEST MANAGEMENT SCIENCE, ELSEVIER, BARKING, GB, vol. 56, no. 9, September 2000 (2000-09-01), pages 825 - 827, XP001063302, ISSN: 1526-498X
SAUER H ET AL: "INCREASED DOXORUBICIN UPTAKE AND TOXICITY IN MULTICELLULAR TUMOUR SPHEROIDS TREATED WITH DC ELECTRICAL FIELDS", BRITISH JOURNAL OF CANCER, LONDON, GB, vol. 80, no. 8, June 1999 (1999-06-01), pages 1204 - 1213, XP001053174, ISSN: 0007-0920
SAUER H ET AL: "INCREASED DOXORUBICIN UPTAKE AND TOXICITY IN MULTICELLULAR TUMOUR SPHEROIDS TREATED WITH DC ELECTRICAL FIELDS", BRITISH JOURNAL OF CANCER, LONDON, GB, vol. 80, no. 8, June 1999 (1999-06-01), pages 1204 - 1213, XP001053174, ISSN: 0007-0920
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