Title:
TREATMENT OF DISEASES ASSOCIATED WITH CYTOKINE PRODUCTION WITH INHIBITORS OF THE TEC FAMILY OF PROTEIN TYROSINE KINASES
Document Type and Number:
WIPO Patent Application WO2001066107
Kind Code:
A3
Abstract:
The present invention relates to a method of treating a condition comprising administering a pharmaceutically effective amount of an inhibitor of the Tec family of protein tyrosine kinases (PTKs). The condition is typically associated with cytokine production. Conditions addressed by the invention include sepsis, septic shock, inflammation, rheumatoid arthritis and Crohn's disease. In one embodiment, the condition is induced by zymosan. The invention also provides the use of an inhibitor of a member or members of the Tec family of PTKs in the manufacture of a medicament for use in the treatment of a condition associated with cytokine production and methods for identifying an inhibitor of a member or members of the Tec family of PTKs which is also suitable for use in the treatment of a condition associated with stimulus-induced cytokine production.
Inventors:
FOXWELL BRIAN MAURICE JOHN (GB)
Application Number:
PCT/GB2001/000949
Publication Date:
March 28, 2002
Filing Date:
March 06, 2001
Export Citation:
Assignee:
KENNEDY RHEUMATOLOGY INST (GB)
FOXWELL BRIAN MAURICE JOHN (GB)
FOXWELL BRIAN MAURICE JOHN (GB)
International Classes:
A61K31/00; A61K31/275; A61K31/277; A61K31/7088; A61K39/395; A61K45/00; A61K48/00; A61P1/00; A61P1/04; A61P1/16; A61P5/14; A61P9/10; A61P11/00; A61P11/06; A61P17/04; A61P17/06; A61P19/02; A61P19/04; A61P25/28; A61P29/00; A61P31/00; A61P31/04; A61P31/18; A61P33/00; A61P35/00; A61P37/06; A61P39/02; A61P41/00; A61P43/00; C07K16/40; C12N15/09; C12Q1/02; C12Q1/48; G01N33/15; G01N33/50; (IPC1-7): A61K31/275; A61K39/395; A61K31/7088; A61K48/00; G01N33/50; A61P31/00; A61P29/00; A61P19/02; A61P1/00
Domestic Patent References:
| WO1999054286A2 | 1999-10-28 | |||
| WO2000056737A2 | 2000-09-28 |
Other References:
KAWAKAMI, T. ET AL.: "An inhibitor of Bruton's tyrosine kinase (BTK) from a fungal extract", FASEB J., vol. 13, no. 4, part 1, 12 March 1999 (1999-03-12), pages A324, XP002182794
TIBBLES H E ET AL: "INHIBITION OF COLLAGEN-INDUCED PLATELET AGGREGATION BY SELECTIVELY TARGETING BRUTON'S TYROSINE KINASE WITH LFM-A13", BLOOD, W.B.SAUNDERS COMPAGNY, ORLANDO, FL, US, vol. 94, no. 10,SUPPL01PT01, 15 November 1999 (1999-11-15), pages 221A, XP001024606, ISSN: 0006-4971
FELDMAN M ET AL: "Anti-TNFalpha therapy is useful in rheumatoid arthritis and Crohn's disease: analysis of the mechanism of action predicts utility in other diseases", TRANSPLANTATION PROCEEDINGS, ORLANDO, FL, US, vol. 30, no. 8, 1 December 1998 (1998-12-01), pages 4126 - 4127, XP002098301, ISSN: 0041-1345
SCHAEFFER E M ET AL: "Tec family kinases in lymphocyte signaling and function", CURRENT OPINION IN IMMUNOLOGY, CURRENT BIOLOGY LTD, XX, vol. 12, no. 3, 1 June 2000 (2000-06-01), pages 282 - 288, XP004257675, ISSN: 0952-7915
TIBBLES H E ET AL: "INHIBITION OF COLLAGEN-INDUCED PLATELET AGGREGATION BY SELECTIVELY TARGETING BRUTON'S TYROSINE KINASE WITH LFM-A13", BLOOD, W.B.SAUNDERS COMPAGNY, ORLANDO, FL, US, vol. 94, no. 10,SUPPL01PT01, 15 November 1999 (1999-11-15), pages 221A, XP001024606, ISSN: 0006-4971
FELDMAN M ET AL: "Anti-TNFalpha therapy is useful in rheumatoid arthritis and Crohn's disease: analysis of the mechanism of action predicts utility in other diseases", TRANSPLANTATION PROCEEDINGS, ORLANDO, FL, US, vol. 30, no. 8, 1 December 1998 (1998-12-01), pages 4126 - 4127, XP002098301, ISSN: 0041-1345
SCHAEFFER E M ET AL: "Tec family kinases in lymphocyte signaling and function", CURRENT OPINION IN IMMUNOLOGY, CURRENT BIOLOGY LTD, XX, vol. 12, no. 3, 1 June 2000 (2000-06-01), pages 282 - 288, XP004257675, ISSN: 0952-7915
Download PDF: