Title:
USE OF ALOXISTATIN IN PREPARING ANTI-VIRAL INFECTION MEDICAMENT
Document Type and Number:
WIPO Patent Application WO/2024/094189
Kind Code:
A1
Abstract:
Provided is use of aloxistatin in preparing an anti-viral infection medicament, in particular, use of aloxistatin in preparing a medicament for treating a related disease caused by orthopoxvirus infection or orthopoxviruses. Aloxistatin can significantly inhibit the activity of poxvirus cysteine protease I7L. It has a potential capability to treat related diseases caused by orthopoxviruses such as monkeypox virus, smallpox virus, or vaccinia virus, and provides an effective drug use strategy for treating major infectious diseases caused by orthopoxviruses such as monkeypox virus.
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Inventors:
YANG HAITAO (CN)
WANG HAOFENG (CN)
ZHANG LEIKE (CN)
ZHANG XIAOYU (CN)
LIU XIAOCE (CN)
YOU TIAN (CN)
LI DONGXU (CN)
DONG XUXUE (CN)
XU JIN (CN)
YANG XIUNA (CN)
RAO ZIHE (CN)
WANG HAOFENG (CN)
ZHANG LEIKE (CN)
ZHANG XIAOYU (CN)
LIU XIAOCE (CN)
YOU TIAN (CN)
LI DONGXU (CN)
DONG XUXUE (CN)
XU JIN (CN)
YANG XIUNA (CN)
RAO ZIHE (CN)
Application Number:
PCT/CN2023/129709
Publication Date:
May 10, 2024
Filing Date:
November 03, 2023
Export Citation:
Assignee:
UNIV SHANGHAI TECHNOLOGY (CN)
WUHAN INST OF VIROLOGY CHINESE ACADEMY (CN)
WUHAN INST OF VIROLOGY CHINESE ACADEMY (CN)
International Classes:
A61K31/336; A61P31/20
Domestic Patent References:
| WO2021209620A1 | 2021-10-21 | |||
| WO2021209620A1 | 2021-10-21 | |||
| WO2006091610A2 | 2006-08-31 | |||
| WO2021231872A1 | 2021-11-18 | |||
| WO2022072504A1 | 2022-04-07 |
Foreign References:
| US20080227688A1 | 2008-09-18 |
Other References:
BYRD, C.M. ET AL.: "Molecular Dissection of the Vaccinia Virus I7L Core Protein Proteinase", JOURNAL OF VIROLOGY, vol. 77, no. 20, 31 October 2003 (2003-10-31), XP002343717, DOI: 10.1128/JVI.77.20.11279-11283.2003
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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