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Title:
USE OF BENZOYLGUANIDINES FOR THE TREATMENT OF NON-INSULIN-DEPENDENT DIABETES MELLITUS
Document Type and Number:
WIPO Patent Application WO2000030624
Kind Code:
A3
Abstract:
(57) Abstract The invention relates to the use of benzoylguanidines of formula (I) wherein R<1> is A; R<2> is Het, CnFmH2n+1-mOp, R<4>, OR<4>, OH, benzyl, CN, Hal, SOq-R<5>, Ph, O-Ph, O-Het, NH-Het, NH2, NHA, NA2 or NH-Ph; R<3> is SO2A'; R<4> is a straight-chain or branched alkyl radical having 1 to 8 C atoms or cycloalkyl having 3 to 8 C atoms which can be unsubstituted or mono-, di- or trisubstituted by A; R<5> is A or Ph; A, A' in each case independently of one another are alkyl having 1 to 6 C atoms, and/or their physiologically acceptable salts and solvates for the production of a medicament for the treatment of non-insulin-dependent diabetes mellitus.

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Inventors:
GERICKE ROLF (DE)
BAUMGARTH MANFRED (DE)
MINCK KLAUS (DE)
MESANGEAU DIDIER (FR)
DOARE LILIANE (FR)
KERGOAT MICHELINE (FR)
Application Number:
PCT/EP1999/008795
Publication Date:
October 05, 2000
Filing Date:
November 16, 1999
Export Citation:
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Assignee:
MERCK PATENT GMBH (DE)
GERICKE ROLF (DE)
BAUMGARTH MANFRED (DE)
MINCK KLAUS (DE)
MESANGEAU DIDIER (FR)
DOARE LILIANE (FR)
KERGOAT MICHELINE (FR)
International Classes:
A61K31/155; A61K31/166; A61K31/40; C07D207/327; A61K31/402; A61P3/10; A61P5/48; C07C279/22; (IPC1-7): A61K31/155; A61K31/40; A61P5/48
Foreign References:
EP0699666A11996-03-06
EP0743301A21996-11-20
EP0699663A11996-03-06
EP0760365A21997-03-05
EP0723963A11996-07-31
EP0708088A11996-04-24
EP0725062A11996-08-07
Other References:
BAUMGARTH M ET AL: "(2-Methyl-5(methylsufonyl)benzoyl) guanidine Na+/H+ antiporter inhibitors", JOURNAL OF MEDICINAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 40, no. 13, 20 June 1997 (1997-06-20), pages 2017 - 2034-34, XP002121770, ISSN: 0022-2623
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