Title:
USE OF A GAMMA -RAR-SPECIFIC AGONIST LIGAND TO INCREASE APOPTOSIS RATE
Document Type and Number:
WIPO Patent Application WO1997013505
Kind Code:
A3
Abstract:
The present invention relates to pharmaceutical and cosmetic compositions comprising at least one agonist ligand, which is specific for receptors of the RAR-gamma type, which are characterized as inducers of apoptosis in at least one cell population in which apoptosis can be induced by activating receptors of the RAR-gamma type. In one aspect of the present invention, there is provided a method of combating photoinduced or chronological ageing of skin, said method comprising administering an effective amount of at least one agonist ligand which is specific for receptors of the RAR-gamma type to combat photoinduced or chronological aging of skin, wherein the agonist ligand has a ratio R which is equal to or greater than 10.
Inventors:
FESUS LASZLO (HU)
SZONDY ZSUZSA (HU)
REICHERT UWE (HU)
SZONDY ZSUZSA (HU)
REICHERT UWE (HU)
Application Number:
PCT/FR1996/001568
Publication Date:
May 29, 1997
Filing Date:
October 08, 1996
Export Citation:
Assignee:
CIRD (FR)
FESUS LASZLO (FR)
SZONDY ZSUZSA (FR)
REICHERT UWE (FR)
FESUS LASZLO (FR)
SZONDY ZSUZSA (FR)
REICHERT UWE (FR)
International Classes:
A61K8/00; A61K8/36; A61K8/368; A61K8/40; A61K8/41; A61K8/46; C07D333/38; A61K8/49; A61K31/19; A61K31/192; A61K31/195; A61K31/34; A61K31/343; A61K31/35; A61K31/352; A61K31/38; A61K31/381; A61K31/40; A61K31/60; A61K45/00; A61P1/16; A61P3/08; A61P3/10; A61P17/00; A61P17/06; A61P29/00; A61P31/12; A61P35/00; A61P37/00; A61P37/08; A61P43/00; C07D207/34; C07D307/91; C07D311/58; (IPC1-7): A61K31/19; A61K31/34; A61K31/35; A61K31/38; A61K31/40; A61K31/60
Domestic Patent References:
| WO1997003682A1 | 1997-02-06 |
Other References:
Z-M. SHAO ET AL.: "P53 independent G0/G1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells.", ONCOGENE, vol. 11, no. 3, 1995, pages 493 - 504, XP000575582
J. CORBEIL ET AL.: "antiproliferative effect of retinoid compounds on Kaposi's sarcoma cells.", J. CLIN. INVEST., vol. 93, no. 5, 1994, pages 1981 - 1986, XP000646558
M.F. BOEHM ET AL.: "design and synthesis of potent retinoid-X receptor selective ligands that induce apoptosis in leukemia cells.", J. MED. CHEM., vol. 38, no. 16, 1995, pages 3146 - 3155, XP000615461
J. CORBEIL ET AL.: "antiproliferative effect of retinoid compounds on Kaposi's sarcoma cells.", J. CLIN. INVEST., vol. 93, no. 5, 1994, pages 1981 - 1986, XP000646558
M.F. BOEHM ET AL.: "design and synthesis of potent retinoid-X receptor selective ligands that induce apoptosis in leukemia cells.", J. MED. CHEM., vol. 38, no. 16, 1995, pages 3146 - 3155, XP000615461
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