Title:
USE OF POTENT, SELECTIVE AND NON TOXIC C-KIT INHIBITORS FOR TREATING TUMOR ANGIOGENESIS
Document Type and Number:
WIPO Patent Application WO2003004006
Kind Code:
A3
Abstract:
The present invention relates to a method for inhibiting tumor angiogenesis comprising administering a c-kit inhibitor to a human in need of such treatment, more particularly a non toxic, potent and selective c-kit inhibitor, wherein said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.
Inventors:
MOUSSY ALAIN (FR)
KINET JEAN-PIERRE (US)
KINET JEAN-PIERRE (US)
Application Number:
PCT/IB2002/003295
Publication Date:
May 30, 2003
Filing Date:
June 28, 2002
Export Citation:
Assignee:
AB SCIENCE (FR)
MOUSSY ALAIN (FR)
KINET JEAN-PIERRE (US)
MOUSSY ALAIN (FR)
KINET JEAN-PIERRE (US)
International Classes:
A61K31/00; A61K31/015; A61K31/095; A61K31/40; A61K31/403; A61K31/404; A61K31/415; A61K31/4709; A61K31/498; A61K31/505; A61K31/506; G01N33/15; A61K31/517; A61K31/519; A61K45/00; A61K45/06; A61P9/00; A61P35/00; A61P43/00; C07D401/04; C07K14/705; C12N9/12; G01N33/50; (IPC1-7): A61K31/404; A61K31/415; A61K31/4709; A61K31/498; A61K31/505; A61K31/506; A61K31/517; A61K31/519; A61K31/095; A61K31/66; A61P35/00
Domestic Patent References:
| WO2002072578A2 | 2002-09-19 | |||
| WO2002055517A2 | 2002-07-18 | |||
| WO2001090104A2 | 2001-11-29 | |||
| WO2001045689A2 | 2001-06-28 | |||
| WO1999021859A1 | 1999-05-06 | |||
| WO1998050356A1 | 1998-11-12 |
Foreign References:
| EP0564409A1 | 1993-10-06 | |||
| DE19844003A1 | 2000-03-30 | |||
| US5792783A | 1998-08-11 |
Other References:
B. D. SMOLICH ET AL: "The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid blasts", BLOOD, vol. 97, no. 5, 1 March 2001 (2001-03-01), pages 1413 - 1421, XP002229742
MA Y ET AL: "INDOLINONE DERIVATIVES INHIBIT CONSTITUTIVELY ACTIVATED KIT MUTANTS AND KILL NEOPLASTIC MAST CELLS", JOURNAL OF INVESTIGATIVE DERMATOLOGY, NEW YORK, NY, US, vol. 114, no. 2, February 2001 (2001-02-01), pages 392 - 394, XP001127437, ISSN: 0022-202X
KRYSTAL G W ET AL: "INDOLINONE TYROSINE KINASE INHIBITORS BLOCK KIT ACTIVATION AND GROWTH OF SMALL CELL LUNG CANCER CELLS", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 61, no. 9, 1 May 2001 (2001-05-01), pages 3660 - 3668, XP001080106, ISSN: 0008-5472
HEINRICH M C ET AL: "INHIBITION OF C-KIT RECEPTOR TYROSINE KINASE ACTIVITY BY STI 571, A SELECTIVE TYROSINE KINASE INHIBITOR", BLOOD, W.B.SAUNDERS COMPAGNY, ORLANDO, FL, US, vol. 96, no. 3, 1 August 2000 (2000-08-01), pages 925 - 932, XP001097629, ISSN: 0006-4971
TRAXLER ET AL: "Protein tyrosine kinase inhibitors in cancer treatment", EXPERT OPINION ON THERAPEUTIC PATENTS, ASHLEY PUBLICATIONS, GB, vol. 7, no. 6, 1997, pages 571 - 588, XP002122590, ISSN: 1354-3776
BOLD G ET AL: "NEW ANILINOPHTHALAZINES AS POTENT AND ORALLY WELL ABSORBED INHIBITORS OF THE VEGF RECEPTOR TYROSINE KINASES USEFUL AS ANTAGONISTS OF TUMOR-DRIVEN ANGIOGENESIS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 43, no. 12, 2000, pages 2310 - 2323, XP000971347, ISSN: 0022-2623
WOOD J M ET AL: "PTK787/ZK 222584, A NOVEL AND POTENT INHIBITOR OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR TYROSINE KINASES, IMPAIRS VASCULAR ENDOTHELIAL GROWTH FACTOR-INDUCED RESPONSES AND TUMOR GROWTH AFTER ORAL ADMINISTRATION", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 60, no. 8, 15 April 2000 (2000-04-15), pages 2178 - 2189, XP000971163, ISSN: 0008-5472
WILKINSON S E ET AL: "SELECTIVE TYROSINE KINASE INHIBITORS", EMERGING DRUGS, ASHLEY PUBLICATIONS, LONDON, GB, vol. 5, no. 3, 2000, pages 287 - 297, XP001062304, ISSN: 1361-9195
MA Y ET AL: "INDOLINONE DERIVATIVES INHIBIT CONSTITUTIVELY ACTIVATED KIT MUTANTS AND KILL NEOPLASTIC MAST CELLS", JOURNAL OF INVESTIGATIVE DERMATOLOGY, NEW YORK, NY, US, vol. 114, no. 2, February 2001 (2001-02-01), pages 392 - 394, XP001127437, ISSN: 0022-202X
KRYSTAL G W ET AL: "INDOLINONE TYROSINE KINASE INHIBITORS BLOCK KIT ACTIVATION AND GROWTH OF SMALL CELL LUNG CANCER CELLS", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 61, no. 9, 1 May 2001 (2001-05-01), pages 3660 - 3668, XP001080106, ISSN: 0008-5472
HEINRICH M C ET AL: "INHIBITION OF C-KIT RECEPTOR TYROSINE KINASE ACTIVITY BY STI 571, A SELECTIVE TYROSINE KINASE INHIBITOR", BLOOD, W.B.SAUNDERS COMPAGNY, ORLANDO, FL, US, vol. 96, no. 3, 1 August 2000 (2000-08-01), pages 925 - 932, XP001097629, ISSN: 0006-4971
TRAXLER ET AL: "Protein tyrosine kinase inhibitors in cancer treatment", EXPERT OPINION ON THERAPEUTIC PATENTS, ASHLEY PUBLICATIONS, GB, vol. 7, no. 6, 1997, pages 571 - 588, XP002122590, ISSN: 1354-3776
BOLD G ET AL: "NEW ANILINOPHTHALAZINES AS POTENT AND ORALLY WELL ABSORBED INHIBITORS OF THE VEGF RECEPTOR TYROSINE KINASES USEFUL AS ANTAGONISTS OF TUMOR-DRIVEN ANGIOGENESIS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 43, no. 12, 2000, pages 2310 - 2323, XP000971347, ISSN: 0022-2623
WOOD J M ET AL: "PTK787/ZK 222584, A NOVEL AND POTENT INHIBITOR OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR TYROSINE KINASES, IMPAIRS VASCULAR ENDOTHELIAL GROWTH FACTOR-INDUCED RESPONSES AND TUMOR GROWTH AFTER ORAL ADMINISTRATION", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 60, no. 8, 15 April 2000 (2000-04-15), pages 2178 - 2189, XP000971163, ISSN: 0008-5472
WILKINSON S E ET AL: "SELECTIVE TYROSINE KINASE INHIBITORS", EMERGING DRUGS, ASHLEY PUBLICATIONS, LONDON, GB, vol. 5, no. 3, 2000, pages 287 - 297, XP001062304, ISSN: 1361-9195
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