Title:
USES OF SUBSTANCES BINDING TO FABP4 FOR DIAGNOSING AND TREATING BLADDER CARCINOMA
Document Type and Number:
WIPO Patent Application WO2004063394
Kind Code:
A3
Abstract:
The invention relates to uses of FABP4 for diagnosing and treating urogenital tumors, especially bladder carcinoma, and for screening for substances for such purposes.
More Like This:
Inventors:
HINZMANN BERND (DE)
DAHL EDGAR (DE)
SPECHT THOMAS (DE)
PILARSKY CHRISTIAN (DE)
HERR ALEXANDER (DE)
DAHL EDGAR (DE)
SPECHT THOMAS (DE)
PILARSKY CHRISTIAN (DE)
HERR ALEXANDER (DE)
Application Number:
PCT/DE2004/000029
Publication Date:
October 14, 2004
Filing Date:
January 08, 2004
Export Citation:
Assignee:
HINZMANN BERND (DE)
DAHL EDGAR (DE)
SPECHT THOMAS (DE)
PILARSKY CHRISTIAN (DE)
HERR ALEXANDER (DE)
DAHL EDGAR (DE)
SPECHT THOMAS (DE)
PILARSKY CHRISTIAN (DE)
HERR ALEXANDER (DE)
International Classes:
C12Q1/68; G01N33/574; (IPC1-7): C12Q1/68
Other References:
GROMOVA I ET AL.: "Protein abundancy and mRNA levels of the adipocyte-type fatty acid binding protein correlate in non-invasive and invasive bladder transitional cell carcinomas", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 13, 1998, pages 379 - 383, XP008031678
CELIS J E ET AL.: "Loss of adipocyte-type fatty acid binding protein and other protein biomarkers is associated with progression of human bladder transitional cell carcinomas", CANCER RESEARCH, vol. 56, no. 20, 1999, pages 4782 - 4790, XP001189628
CELIS A ET AL.: "Short-term culturing of low-grade superficial bladder transitional cell carcinomas leads to changes in the expression levels of several proteins involved in key cellular activities", ELECTROPHORESIS, vol. 20, no. 2, 1999, pages 355 - 361, XP002287087
VAN DONGEN M J P ET AL.: "Structure-based screening as apllied to human FABP4: A highly efficient alternative to HTS for hit generation", THE JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 124, 9 October 2002 (2002-10-09), pages 11874 - 11880, XP002287088
BENNETT J H ET AL.: "Immunohistochemical identification of tumours of adipocytic differentiation using an antibody to aP2 protein", JOURNAL OF CLINICAL PATHOLOGY, vol. 48, 1995, pages 950 - 954, XP008031677
YANG T T ET AL.: "aP2 protein expression as a diagnostic marker in soft tissue tumours", SARCOMA, no. 5, 2001, pages 139 - 142, XP008031680
CELIS J E ET AL.: "Loss of adipocyte-type fatty acid binding protein and other protein biomarkers is associated with progression of human bladder transitional cell carcinomas", CANCER RESEARCH, vol. 56, no. 20, 1999, pages 4782 - 4790, XP001189628
CELIS A ET AL.: "Short-term culturing of low-grade superficial bladder transitional cell carcinomas leads to changes in the expression levels of several proteins involved in key cellular activities", ELECTROPHORESIS, vol. 20, no. 2, 1999, pages 355 - 361, XP002287087
VAN DONGEN M J P ET AL.: "Structure-based screening as apllied to human FABP4: A highly efficient alternative to HTS for hit generation", THE JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 124, 9 October 2002 (2002-10-09), pages 11874 - 11880, XP002287088
BENNETT J H ET AL.: "Immunohistochemical identification of tumours of adipocytic differentiation using an antibody to aP2 protein", JOURNAL OF CLINICAL PATHOLOGY, vol. 48, 1995, pages 950 - 954, XP008031677
YANG T T ET AL.: "aP2 protein expression as a diagnostic marker in soft tissue tumours", SARCOMA, no. 5, 2001, pages 139 - 142, XP008031680
Download PDF:
Previous Patent: MEASUREMENT OF ANALYTE CONCENTRATION
Next Patent: METHOD FOR DEGREASING ANIMAL SKINS AT ULTRALOW INTERFACIAL SURFACE TENSION
Next Patent: METHOD FOR DEGREASING ANIMAL SKINS AT ULTRALOW INTERFACIAL SURFACE TENSION