Title:
VIRAL MARKER
Document Type and Number:
WIPO Patent Application WO2004011677
Kind Code:
A3
Abstract:
The invention relates to herpesviruses genetic markers, and provides methods and materials for assessing the virulence of herpesviruses comprising the use of genetic markers (e.g. within the herpesvirus DNA polymerase (ORF30 in Equine herpesvirus type 1). In another aspect the invention provides vaccines based on the manipulation of the markers disclosed.
Inventors:
DAVIS POYNTER NICK (GB)
NUGENT JOSEPHINE (GB)
BIRCH-MACHIN IAN (GB)
ALLEN GEORGE (US)
NUGENT JOSEPHINE (GB)
BIRCH-MACHIN IAN (GB)
ALLEN GEORGE (US)
Application Number:
PCT/GB2003/003279
Publication Date:
June 17, 2004
Filing Date:
July 23, 2003
Export Citation:
Assignee:
ANIMAL HEALTH TRUST (GB)
DAVIS POYNTER NICK (GB)
NUGENT JOSEPHINE (GB)
BIRCH-MACHIN IAN (GB)
ALLEN GEORGE (US)
DAVIS POYNTER NICK (GB)
NUGENT JOSEPHINE (GB)
BIRCH-MACHIN IAN (GB)
ALLEN GEORGE (US)
International Classes:
C07K14/03; C12N7/04; C12Q1/70; C12Q1/68; (IPC1-7): C12Q1/68
Domestic Patent References:
| WO2002009750A2 | 2002-02-07 | |||
| WO1998026049A1 | 1998-06-18 |
Other References:
SMITH K C ET AL: "Virulence of the V592 isolate of equid herpesvirus-1 in ponies", JOURNAL OF COMPARATIVE PATHOLOGY, vol. 122, no. 4, May 2000 (2000-05-01), pages 288 - 297, XP009023817, ISSN: 0021-9975
PELOSI E ET AL: "A Herpes Simplex Virus DNA Polymerase Mutation That Specifically Attenuates Neurovirulence in Mice", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 252, no. 2, 20 December 1998 (1998-12-20), pages 364 - 372, XP004445507, ISSN: 0042-6822
KIRISAWA RIKIO ET AL: "Comparison of the genomes of attenuated equine herpesvirus-1 strains with their parent virulent strain", VIROLOGY, vol. 200, no. 2, 1994, pages 651 - 660, XP002268362, ISSN: 0042-6822
TELFORD E A R ET AL: "THE DNA SEQUENCE OF EQUINE HERPESVIRUS-1", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 189, no. 1, 1992, pages 304 - 316, XP000886227, ISSN: 0042-6822
VAN MAANEN C ET AL: "Equine influenza virus infections: an update.", THE VETERINARY QUARTERLY. NETHERLANDS JUN 2002, vol. 24, no. 2, June 2002 (2002-06-01), pages 79 - 94, XP009024929, ISSN: 0165-2176
TELFORD E A ET AL: "The DNA sequence of equine herpesvirus-4", JOURNAL OF GENERAL VIROLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, READING, GB, vol. 79 ( Pt 5), May 1998 (1998-05-01), pages 1197 - 1203, XP002225299, ISSN: 0022-1317
HUANG JIN-AN ET AL: "Polymorphism of open reading frame 71 of equine herpesvirus-4 (EHV-4) and EHV-1", JOURNAL OF GENERAL VIROLOGY, vol. 83, no. 3, March 2002 (2002-03-01), pages 525 - 531, XP002268365, ISSN: 0022-1317
PELOSI E ET AL: "A Herpes Simplex Virus DNA Polymerase Mutation That Specifically Attenuates Neurovirulence in Mice", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 252, no. 2, 20 December 1998 (1998-12-20), pages 364 - 372, XP004445507, ISSN: 0042-6822
KIRISAWA RIKIO ET AL: "Comparison of the genomes of attenuated equine herpesvirus-1 strains with their parent virulent strain", VIROLOGY, vol. 200, no. 2, 1994, pages 651 - 660, XP002268362, ISSN: 0042-6822
TELFORD E A R ET AL: "THE DNA SEQUENCE OF EQUINE HERPESVIRUS-1", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 189, no. 1, 1992, pages 304 - 316, XP000886227, ISSN: 0042-6822
VAN MAANEN C ET AL: "Equine influenza virus infections: an update.", THE VETERINARY QUARTERLY. NETHERLANDS JUN 2002, vol. 24, no. 2, June 2002 (2002-06-01), pages 79 - 94, XP009024929, ISSN: 0165-2176
TELFORD E A ET AL: "The DNA sequence of equine herpesvirus-4", JOURNAL OF GENERAL VIROLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, READING, GB, vol. 79 ( Pt 5), May 1998 (1998-05-01), pages 1197 - 1203, XP002225299, ISSN: 0022-1317
HUANG JIN-AN ET AL: "Polymorphism of open reading frame 71 of equine herpesvirus-4 (EHV-4) and EHV-1", JOURNAL OF GENERAL VIROLOGY, vol. 83, no. 3, March 2002 (2002-03-01), pages 525 - 531, XP002268365, ISSN: 0022-1317
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