Title:
beta-ADRENOCEPTOR GENETIC POLYMORPHISMS AND OBESITY
Document Type and Number:
WIPO Patent Application WO2002071070
Kind Code:
A3
Abstract:
The present invention provides a method for identifying a subject having a risk of developing obesity, coronary microvascular dysfunction, or hypertension, comprising detection of the presence of a single nucleotide polymorphism (SNP) in a nucleic acid encoding an element of at least one beta -adrenergic receptor from the subject. The presence of the SNP is correlated with obesity, coronary microvascular dysfunction, or hypertension, and thereby identifies the subject as having a risk of developing obesity, coronary microvascular dysfunction, or hypertension. The subject invention also provides methods of identifying patients likely to benefit from the prescription of beta blocker hypertension medications. In various embodiments, the nucleic acids detected include those genes encoding ADRB1 ( beta >123s< protein alpha subunit). Methods of treating identified individuals are also provided.
More Like This:
| WO/2014/015183 | OPHTHALMIC FORMULATION AND METHOD FOR AMELIORATING PRESBYOPIA |
| JP2022132186 | PHARMACEUTICAL COMPOSITION |
| JP4166218 | Amino-propanol derivative |
Inventors:
JOHNSON JULIE A (US)
Application Number:
PCT/US2002/004332
Publication Date:
December 31, 2003
Filing Date:
February 12, 2002
Export Citation:
Assignee:
UNIV FLORIDA (US)
JOHNSON JULIE A (US)
JOHNSON JULIE A (US)
International Classes:
A61K31/137; C12Q1/68; G01N33/566; (IPC1-7): G01N33/566
Domestic Patent References:
| WO2001011039A2 | 2001-02-15 |
Other References:
BORJESSON M ET AL: "A novel polymorphism in the gene coding for the beta1-adrenergic receptor associated with survival in patients with heart failure.", EUROPEAN HEART JOURNAL, vol. 21, no. 22, November 2000 (2000-11-01), pages 1853 - 1858, XP002222351, ISSN: 0195-668X
MASON DEBORAH A ET AL: "A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 18, 30 April 1999 (1999-04-30), pages 12670 - 12674, XP002222352, ISSN: 0021-9258
BENGTSSON KRISTINA ET AL: "Polymorphism in the beta1-adrenergic receptor gene and hypertension.", CIRCULATION, vol. 104, no. 2, 10 July 2001 (2001-07-10), pages 187 - 190, XP002222353, ISSN: 0009-7322
MASON DEBORAH A ET AL: "A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 18, 30 April 1999 (1999-04-30), pages 12670 - 12674, XP002222352, ISSN: 0021-9258
BENGTSSON KRISTINA ET AL: "Polymorphism in the beta1-adrenergic receptor gene and hypertension.", CIRCULATION, vol. 104, no. 2, 10 July 2001 (2001-07-10), pages 187 - 190, XP002222353, ISSN: 0009-7322
Download PDF:
Previous Patent: METHOD OF ANALYZING SPECIMEN WITH THE USE OF SPECIFIC BOND
Next Patent: ASSAYS INVOLVING REPORTER SYSTEMS ON CARRIERS
Next Patent: ASSAYS INVOLVING REPORTER SYSTEMS ON CARRIERS