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WO/2024/099103A1 |
A polypeptide having an analgesic effect and a use thereof. The polypeptide or a construct thereof can be used as a positive allosteric modulator and used in combination with a TRPV1 receptor agonist to enhance an agonistic effect on TRP...
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WO/2024/099445A1 |
A site-specific PEGylated heteromeric protein or polypeptide, and a preparation method therefor and the use thereof. Firstly, provided is a method for the site-specific PEGylation of a protein or polypeptide. The method comprises providi...
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WO/2024/098494A1 |
A neurotoxic amyloid-β protein dimer, and a preparation method therefor and the use thereof. The method comprises: making an amyloid-β protein monomer, i.e., an Aβ monomer, generate a metastable Aβ polymer 1 in an acidic environment,...
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WO/2024/098848A1 |
The present application relates to a preparation method for a bird's nest peptide: mixing bird's nest and water, and stewing to prepare a cooked bird's nest material; homogenizing the cooked bird's nest material to prepare a bird's nest ...
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WO/2024/102190A2 |
Provided herein are affinity agents comprising ligands that specifically bind target molecules. The affinity agents are useful for binding, isolation, and/or purifications.
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WO/2024/098718A1 |
Provided are a novel long-acting polypeptide compound, a composition, and a use thereof. In the long-acting polypeptide compound, the substitution of an amino acid at a key particular position enhances the stability, activity and hydroly...
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WO/2024/099428A1 |
Provided are a membrane fusion inhibitor for inhibiting HIV and a drug-resistant strain thereof, a derivative thereof, a pharmaceutical composition thereof, and a pharmaceutical use thereof.
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WO/2024/102605A1 |
The present disclosure relates generally to improved methods of preparing glycoconjugates. The methods comprise using a reducing mixture containing acetoxyborohydrides prepared in-situ for conjugating a saccharide to a carrier protein.
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WO/2024/101624A1 |
The present invention relates to a method for purifying botulinum toxin (BTX). More specifically, the method is performed in the order of purification steps using cation exchange chromatography (CEX), hydrophobic interaction chromatograp...
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WO/2024/059235A3 |
The disclosure provides methods of purifying a target protein, e.g., an antibody, from a host cell such as a mammalian cell using purification protocols incorporating harvest recovery operations comprising a continuous solids discharge d...
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WO/2024/101431A1 |
The purpose of the present invention is to provide a method for synthesizing a peptide or a long-chain peptide that uses amino acids including an amino acid containing a certain number of hydrophobic amino acids and an amino acid with a ...
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WO/2024/093915A1 |
Provided are a protein comprising an amino acid sequence capable of binding to a substrate GPRP peptide fragment, a fibrinogen like protein 1 (FGL1) comprising the amino acid sequence, and a fibrinogen domain (FD) thereof, and an individ...
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WO/2024/096505A1 |
The present invention relates to a composition for improving the removal of impurities in protein purification by affinity chromatography, the composition comprising a nonionic surfactant, and a method for purifying a target protein by u...
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WO/2024/096378A1 |
The present invention relates to a pretreatment method for isolating a TGF-β3 protein from E. coli and purifying same with high efficiency and high purity, and a TGF-β3 protein purification method comprising the pretreatment method. Th...
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WO/2024/096023A1 |
It has been discovered that by using, as a capturing agent, sulfite ions, hydrogen sulfite ions, or a compound that generates these ions, dibenzofulvene or a dibenzofulvene derivative can be captured, and the dibenzofulvene or dibenzoful...
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WO/2024/096880A1 |
What is described herein relates to a method for optimizing purification conditions of a protein of interest comprising: a) prediction of filtration performance of a protein of interest based on the hydrophobicity of said protein of inte...
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WO/2024/094152A1 |
The present invention relates to a spiro compound, and a preparation method and use thereof. The spiro compound is as shown in formula I, has 3CL protease inhibitory activity, can effectively inhibit RNA virus replication of protein comp...
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WO/2024/096344A1 |
The present invention relates to a method for purifying high purity hyaluronidase. More particularly, the present invention confirms that hyaluronidase exhibiting high purity and high specific activity can be purified by performing a two...
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WO/2024/090489A1 |
The present invention pertains to a method for producing a radioactive pharmaceutical composition which is a liquid and which comprises, as an active ingredient, a radioactive-labeled antibody, which is an antibody labeled with a radionu...
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WO/2024/087784A1 |
The present invention belongs to the technical field of genetic engineering and synthetic biology. Provided are a recombinant type XVII humanized collagen expressed in yeast and a preparation method therefor, and particularly provided ar...
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WO/2024/090815A1 |
The present invention relates to a technology for producing human papillomavirus virus-like particles from a plant and, more specifically, to a technology for effectively producing human papillomavirus virus-like particles in a plant chl...
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WO/2024/091527A1 |
Methods of using a separation media to isolate a target molecule that includes a carbohydrate are disclosed. The separation media includes a support substrate and a plurality of separation ligands immobilized on the support substrate. Th...
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WO/2024/092121A2 |
Systems and methods are described herein enabling the profiling of local microenvironments across the sialylated proteome via proximity labeling. In one aspect, conjugates are described herein having composition and electronic structure ...
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WO/2024/087860A1 |
The present invention relates to a method for obtaining high-purity and high-stability recombinant human albumin by adding medium- and long-chain fatty acid ligands and removing a protein having charge heterogeneity by means of anion or/...
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WO/2024/091120A1 |
The invention provides a method for providing a cargo-conjugated protein (130), wherein the method comprises: a first conjugation stage (510) comprising exposing a protein (100) to a linker (20) to provide a linker-conjugated protein (12...
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WO/2024/088087A1 |
The present invention relates to the field of medical biology, and specifically to expression of a human papillomavirus (HPV) 68 L1 protein, and virus-like particles (VLPs) and a preparation method therefor. The amino acid sequence of th...
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WO/2024/085235A1 |
The present invention discloses a method for producing cyclic peptide crystals, the method comprising bringing a cyclic peptide into contact with a specific solvent.
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WO/2024/086781A2 |
According to some aspects, systems and methods for characterizing phosphoserine-containing polypeptides are described. In some embodiments, a phosphoserine residue of a polypeptide may be converted to a dehydroalanine residue. Some aspec...
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WO/2024/082609A1 |
A device for preparing a bioactive peptide. The device comprises a preparation box (1) mounted on a supporting frame body, wherein a net cover (2) having two ends in communication with each other is fixedly mounted in the preparation box...
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WO/2024/078578A1 |
The present invention belongs to the technical field of oligosaccharides and glycoconjugates thereof, and specifically relates to a sialic acid (α-(2→6))-D-aminopyran galactose derivative or a salt thereof, a glycoconjugate and a prep...
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WO/2024/081963A2 |
Described are labeling kits for proximity labeling of biomolecules. A kit may include a plurality of first tagged spacer precursors, a plurality of second tagged spacer precursors, a plurality of tagged enzymes, and a plurality of connec...
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WO/2024/081302A1 |
A method of covalently modifying tyrosines, tryptophans, and pyrrolated lysines in a protein comprising reacting the side chains of the amino acids with a cyclic imine Mannich electrophile appended to a ligand that binds to the protein; ...
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WO/2024/078487A1 |
Provided herein are methods for modifying an antibody by attaching a molecule with a functional handle to the antibody.
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WO/2024/080933A1 |
The invention relates to a method of separating protein fractions from a protein sample comprising the steps of dispersing the protein sample in a deep eutectic solvent to form a dispersion, treating the dispersion with elevated temperat...
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WO/2024/080333A1 |
The present inventors found that a target cyclic peptide compound can be efficiently produced while preventing epimerization and reducing multimer formation, by linking the N-terminal amino acid residue with the C-terminal amino acid res...
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WO/2024/081928A1 |
The present invention relates to a hemoglobin protein composition comprising biologically active hemoglobin and less than 2% methemoglobin (metHb) wherein the metHb is maintained below 2% after reoxygenation of hemoglobin. Furthermore, h...
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WO/2024/075024A1 |
This invention relates to methods for purifying type II collagen from cartilage tissue. The present invention also relates to a type II collagen composition, and the use of the type II collagen composition as a dietary supplement or trea...
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WO/2024/075813A1 |
Provided are: a novel diketopiperazine compound for rapid and easy synthesis of various polypeptides; and a method for manufacturing the same. The diketopiperazine compound is represented by general formula (1). (In the formula, R1, R2, ...
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WO/2024/074159A1 |
A method for preparing a small-molecule ass-hide glue polypeptide product. The method comprises the following steps: S1. pretreatment of ass-hide glue: crushing ass-hide glue blocks as raw materials, dissolving same by adding water, perf...
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WO/2024/077083A2 |
The present disclosure provides compositions and methods related to the purification and/or isolation of antibodies. In particular, the present disclosure provides novel peptide ligands capable of targeting the fragment antigen binding (...
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WO/2024/071960A1 |
The present invention relates to: a peptide tag based on a dispersed His-tag and charged and hydrophobic amino acids forming a self-assembly; a fusion protein in which the tag and a target protein are fused; and a target protein purifica...
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WO/2024/067531A1 |
Provided is a dual-targeting compound against FAP and integrin αvβ3. The targeting compound and a radionuclide marker thereof can synergistically target a FAP target and an integrin αvβ3 target in tumors, such that the number of and ...
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WO/2024/068683A1 |
A stationary phase for use in affinity chromatography for recovering adeno-associated virus (AAV) vectors (3) from a solution. The stationary phase comprises a porous polymer matrix (1) having a mean flow pore size of 0.1-2.0 µm, wherei...
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WO/2024/071956A1 |
The present invention relates to a fusion polypeptide and a method for purifying a target protein by using same, the polypeptide having any one from among a His tag, a HAT tag and an HQ tag, and an α-helix peptide tag of which the major...
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WO/2024/071320A1 |
The present invention provides a method with which it is possible to simply produce a peptide including an aromatic six-membered ring in the scaffold. The present invention pertains to a production method for a compound represented by fo...
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WO/2024/067535A1 |
Provided are a small peptide and a use thereof in mucosal repair. The small peptide is selected from a basic small peptide having a sequence as shown in SEQ ID NO. 1 or SEQ ID NO. 2 or a lead small peptide containing the basic small pept...
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WO/2024/071008A1 |
The present invention addresses the problem of providing a method in which an antigen molecule is efficiently isolated from and detected in an antigen-antibody complex in a biological specimen. Provided is a method which isolates an an...
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WO/2024/073442A1 |
Disclosed are methods for isolating full-length intercellular proteins from a complex, multicellular environment. The disclosed methods include growing cells in the complex environment in the presence of an amino acid or alkanoic acid an...
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WO/2024/068682A1 |
The present disclosure provides a chromatography ligand defined by Formula I: wherein: X1 is selected from CO and SO2; each of R1-R5 is independently selected from H, F, Cl, O, N, S, C1-3 alkyl, and C1- 3 alkyl-X2; any two adjacent moiet...
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WO/2024/071964A1 |
The present invention relates to: a fusion polypeptide in which a His tag is fused with a peptide tag having main amino acids composed of charged and polar amino acids; a fusion protein in which the fusion polypeptide is fused with a tar...
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